Controlling Nutritional Status score is superior to Prognostic Nutritional Index score in predicting survival and complications in pancreatic ductal adenocarcinoma: a Chinese propensity score matching study
Controlling Nutritional Status score is superior to Prognostic Nutritional Index score in predicting survival and complications in pancreatic ductal adenocarcinoma: a Chinese propensity score matching study
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控制营养状况评分在预测胰腺导管腺癌生存和并发症方面优于预后营养指数评分：一项中国倾向评分匹配研究
DOI：
10.1017/s0007114520002299
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发表时间：
2020-12-14
影响因子：
3.6
通讯作者：
Fu, De-Liang
中科院分区：
文献类型：
--
作者：
Mao, Yi-Shen;Hao, Si-Jie;Fu, De-Liang
术前营养状况对于预测术后结果起着重要作用。预后营养指数（PNI）和控制营养状况（CONUT）是评估患者营养状况的良好工具。它们已被用于预测各种恶性肿瘤的结果，但很少有研究关注胰腺腺癌（PDAC）患者。共有 306 名 PDAC 患者入组。引入倾向得分匹配（PSM）方法来消除基线不等价性。具有不同PNI（或CONUT）评分的患者表现出不相等的基线特征，营养状况受损的患者与更晚期的肿瘤分期相关。 PSM 后，基线特征得到了很好的平衡。两个低 PNI (= 3) 都是总生存率较差的独立危险因素 (P < 0 中心点 05)，并且 PSM 后结果保持不变。生存分析表明，低 PNI 和高 CONUT 评分的患者均与较差的生存相关，并且 PSM 后结果保持不变。 AUC结果表明CONUT在预测并发症和生存方面可能具有更高的敏感性和特异性。术前低 PNI (= 3) 评分可能是 PDAC 患者预后和手术并发症的可靠预测因子。与 PNI 相比，CONUT 可能更有效。
Preoperative nutritional status plays an important role in predicting postoperative outcomes. Prognostic Nutritional Index (PNI) and Controlling Nutritional Status (CONUT) are good tools to assess patients' nutritional status. They have been used in predicting outcomes in various malignancies, but few studies have focused on pancreatic adenocarcinoma (PDAC) patients. Totally, 306 PDAC patients were enrolled. The propensity score matching (PSM) method was introduced to eliminate the baseline inequivalence. Patients with different PNI (or CONUT) scores showed inequivalence baseline characteristics, and patients with compromised nutritional status were related with a more advanced tumour stage. After PSM, the baseline characteristics were well balanced. Both low PNI (= 3) were independent risk factors for poor overall survival (P < 0 center dot 05), and the result remained the same after PSM. Survival analysis demonstrated both patients with low PNI and high CONUT score were associated with poorer survival, and the result remained the same after PSM. The results of AUC indicated that CONUT might have a higher sensitivity and specificity in predicting complications and survival. Preoperative low PNI (= 3) scores might be reliable predictors of prognosis and surgical complications in PDAC patients. Compared with PNI, CONUT might be more effective.