Histomorphometric study on the effects of age on orthodontic tooth movement and alveolar bone turnover in rats
Histomorphometric study on the effects of age on orthodontic tooth movement and alveolar bone turnover in rats
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DOI：
10.1111/j.1600-0722.2007.00428.x
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发表时间：
2007-04-01
影响因子：
1.9
通讯作者：
Sahara, Noriyuki
中科院分区：
文献类型：
--
作者：
Misawa-Kageyama, Yasuko;Kageyama, Toru;Sahara, Noriyuki
本研究的目的是调查，在大鼠模型中，年龄对牙齿移动量的影响和随之而来的变化，牙槽骨周转活动附近的正畸治疗的牙根。实验选用10、30、50、80周龄四个年龄组的大鼠48只。用镍钛合金螺旋弹簧向近中倾斜上颌第一磨牙，持续力10cN，持续2周。48只年龄匹配的未治疗大鼠用作对照。组织形态计量学评估牙槽骨转换的变化。牙齿移动开始两周后，牙齿移动量随着年龄的增长而减少，并且在四个年龄组之间存在显着差异。组织形态计量学研究表明，在所有的实验组，牙槽骨的营业额显着增加，与每个年龄匹配的未处理组相比。然而，增长率以与年龄相关的方式下降。这些结果表明，年龄依赖性减少牙槽骨周转活动，在机械力的反应，可能会产生负面影响的牙齿移动量。
The aim of this study was to investigate, in a rat model, the effects of age on the amount of tooth movement and concomitant changes in alveolar bone turnover activity adjacent to orthodontically treated tooth roots. Rats (n = 48) of four different age groups (10, 30, 50, and 80 wk of age) were used in the experiment. Maxillary first molars were tipped mesially with a nickel titanium alloy coil-spring for 2 wk by a continuous force of 10 cN. Forty-eight age-matched untreated rats were used as controls. The changes in alveolar bone turnover were assessed histomorphometrically. Two weeks after the start of tooth movement, the amount of tooth movement was found to decrease with age and was significantly different among the four age groups. The histomorphometric study demonstrated that, in all experimental groups, turnover of alveolar bone increased significantly compared with that of each age-matched untreated group. However, the rate of increase decreased in an age-related manner. These results suggest that the age-dependent decrease in alveolar bone turnover activity, in response to mechanical forces, may negatively affect the amount of tooth movement.