Time-dependent effect of transcranial direct current stimulation on the enhancement of working memory
Time-dependent effect of transcranial direct current stimulation on the enhancement of working memory
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DOI：
10.1097/wnr.0b013e3282f2adfd
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发表时间：
2008-01-08
期刊：
影响因子：
1.7
通讯作者：
Kim, Yun-Hee
中科院分区：
文献类型：
--
作者：
Ohn, Suk Hoon;Park, Chang-II;Kim, Yun-Hee
采用经颅直流电刺激（tDCS）刺激左侧前额叶皮层，研究了tDCS对工作记忆的时间依赖性影响。这项单盲、假对照的交叉研究招募了15名健康参与者。在1 mA阳极或假tDCS之前、期间和之后30分钟进行三背言语工作记忆任务。与假刺激相比，阳极tDCS显著改善了工作记忆性能。在tDCS应用20分钟后，反应的准确性显著增加，并且在刺激30分钟后进一步增强。刺激完成后，这种效果维持30分钟。这些结果表明，tDCS在1 mA增强工作记忆的时间依赖性的方式至少30分钟的健康参与者。
The time-dependent effect of transcranial direct current stimulation (tDCS) on working memory was investigated by applying anodal stimulation over the left prefrontal cortex. This single-blind, sham-controlled crossover study recruited 15 healthy participants. A three-back verbal working-memory task was performed before, during, and 30 min after 1 mA anodal or sham tDCS. Anodal tDCS, compared with sham stimulation, significantly improved working-memory performance. Accuracy of response was significantly increased after 20 min of tDCS application, and was further enhanced after 30 min of stimulation. This effect was maintained for 30 min after the completion of stimulation. These results suggest that tDCS at 1 mA enhances working memory in a time-dependent manner for at least 30 min in healthy participants.