Molecular mechanisms underlying sex change in hermaphroditic groupers
Molecular mechanisms underlying sex change in hermaphroditic groupers
复制标题
雌雄同体石斑鱼性别变化的分子机制
DOI：
10.1007/s10695-008-9219-0
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发表时间：
2010-06
影响因子：
2.9
通讯作者：
Gui, Jian-Fang
中科院分区：
文献类型：
--
作者：
Zhou, Li;Gui, Jian-Fang
Groupers are widely distributed throughout the tropical and subtropical waters of the world and are regarded as a favourite marine food fish. However, their large-scale aquaculture has been hindered by the rarity of natural males. Being protogynous hermaphrodites, groupers have been considered as study model for development and reproduction, especially for sex determination or sex differentiation, owing to the advantage that grouper gonad development undergoes transition from ovary to intersexual gonad and then to testis, and primordial germ cells and different stages of gametic cells during oogenesis and spermatogenesis are synchronously observed in the transitional gonads. Recently, a series of genes related to the reproduction regulation or sex differentiation have been identified in the groupers, mainly by researchers in China. One important finding was that the grouper gene, doublesex/male abnormal 3-related transcription factor 1 (DMRT1), is not only differentially expressed in gonads at different stages, but that it is also restricted to specific stages and specific cells of spermatogenesis. Grouper DMRT1 protein exists only in spermatogonia, primary spermatocytes and secondary spermatocytes, but not in the supporting Sertoli cells. Moreover, no introns were found in the grouperDMRT1, and no duplicatedDMRT1genes were detected. The finding implies that the intronlessDMRT1that is able to undergo rapid transcriptional turnover might be a significant gene for stimulating spermatogenesis in the protogynous hermaphroditic gonad. Additionally, we have found that grouper expression of sex-determining region Y-related high-mobility group-box gene 3 (SOX3) is a significant time point for enterable gametogenesis of primordial germ cells, because SOX3 is obviously expressed and localized in primordial germ cells. AsSOX3continues to express, the SOX3-positive primordial germ cells develop toward oogonia and then oocytes, whereas, whenSOX3expression is ceased, the SOX3-positive primordial germ cells develop toward spermatogonia. Therefore, we suggest that SOX3, as a transcription factor, might have more important roles in oogenesis than in spermatogenesis. Based on the findings, a hypothetic molecular mechanism underlying sex change is proposed in the hermaphroditic groupers, and some candidate genes related to the grouper sex change are also suggested for further research.
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影响因子：
2.7
作者：
Weimin Zhang;Jing Tian;Lihong Zhang;Yong Zhang;Xin Li;Hao-ren Lin
通讯作者：
Weimin Zhang;Jing Tian;Lihong Zhang;Yong Zhang;Xin Li;Hao-ren Lin
影响因子：
2.7
作者：
W. Li;Dan Chen;A. Wong;Hao-ran Lin
通讯作者：
W. Li;Dan Chen;A. Wong;Hao-ran Lin
DOI：
10.1016/j.cbpb.2005.12.012
发表时间：
2006-03
期刊：
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
影响因子：
--
作者：
Guangyi Ji;Li Zhou;Yang Wang;W. Xia;J. Gui
通讯作者：
Guangyi Ji;Li Zhou;Yang Wang;W. Xia;J. Gui
影响因子：
3.3
作者：
R. Reinboth
通讯作者：
R. Reinboth
DOI：
--
发表时间：
1993
期刊：
--
影响因子：
--
作者：
P. Heemstra;J. Randall
通讯作者：
P. Heemstra;J. Randall