Resistance to nonnucleoside reverse-transcriptase inhibitors and prevalence of HIV type 1 non-B subtypes are increasing among persons with recent infection in Spain
Resistance to nonnucleoside reverse-transcriptase inhibitors and prevalence of HIV type 1 non-B subtypes are increasing among persons with recent infection in Spain
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DOI：
10.1086/496982
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发表时间：
2005-11-01
影响因子：
11.8
通讯作者：
Soriano, V
中科院分区：
文献类型：
--
作者：
de Mendoza, C;Rodriguez, C;Soriano, V
1997-2004年西班牙发现的198名经历人类免疫缺陷病毒（HIV）血清转化的人中，耐药突变的患病率为12.1%。随着时间的推移，K103N 和非 B 亚型显着增加。在 8 对夫妇和 2 个集群（每组 3 人）中发现了艾滋病毒感染在血清转化期间的传播。
The prevalence of drug resistance mutations was 12.1% among 198 persons who experienced human immunodeficiency virus (HIV) seroconversion identified in Spain during 1997-2004. There was a significant increase of K103N and of non-B subtypes over time. Transmission of HIV infection around the time of seroconversion was shown in 8 couples and in 2 clusters of 3 individuals.