Efficient tetanus toxoid immunization on vitamin D supplementation
Efficient tetanus toxoid immunization on vitamin D supplementation
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DOI：
10.1038/ejcn.2010.276
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发表时间：
2011-03-01
影响因子：
4.7
通讯作者：
Worm, M.
中科院分区：
文献类型：
--
作者：
Heine, G.;Drozdenko, G.;Worm, M.
背景/目标：维生素 D 介导免疫调节功能，其缺乏与免疫疾病患病率增加有关。补充维生素 D 可能具有治疗作用，例如对于红斑狼疮患者。然而，它对已建立的回忆免疫反应的影响尚不确定。 受试者/方法：总共 32 名个体被随机分配到安慰剂对照、双盲环境中，并接受维生素 D（每天 2000 IU）为期 10 周，随后进行破伤风类毒素 (TT) 加强免疫。结果：在补充维生素 D 期间，25-羟基维生素 D 血清浓度中位数增加至 80.3 nM，正如预期的那样，在缺乏紫外线的冬季，安慰剂组的该值下降至 29.1 nM。维生素 D 组的 TT 特异性免疫球蛋白 G (IgG) 增强效率稍高 (P=0.04)。 25-羟基维生素D水平的增加与TT-IgG血清浓度的增加相关。两组间特异性血清 IgA 和特异性抗体分泌细胞的诱导相当。因此，TT 特异性和多克隆触发的 T 细胞细胞因子谱也稳定。结论：维生素 D 补充是成功的，加强免疫有效诱导了特异性抗体滴度。欧洲临床营养杂志 (2011) 65, 329-334; doi：10.1038/ejcn.2010.276； 2011 年 1 月 12 日在线发布
Background/Objectives: Vitamin D mediates immunomodulatory functions, and its deficiency has been associated with an increased prevalence of immunological diseases. The supplementation of vitamin D might be therapeutically beneficial, for example, in lupus erythematosus patients. However, its affect on established recall immune responses is undefined.Subjects/Methods: In all, 32 individuals were randomized in a placebo controlled, double-blind setting, and received vitamin D (daily 2000 IU) for 10 weeks followed by tetanus toxoid (TT) booster immunization.Results: During vitamin D supplementation the median 25-hydroxyvitamin D serum concentration increased to 80.3 nM, which as expected decreased in the placebo group to 29.1 nM during the ultraviolet-deprived winter months. The TT-specific immunoglobulin G (IgG) boost efficiency was marginal higher in the vitamin D group (P=0.04). The increase of the 25-hydroxyvitamin D levels correlated with the increase of TT-IgG serum concentrations. The induction of specific serum IgA and specific antibody secreting cells was comparable between both groups. Accordingly, the TT-specific and polyclonally triggered T-cell cytokine profiles were stable as well.Conclusions: Vitamin D supplementation was successful and booster immunization induced efficiently specific antibodies titers. European Journal of Clinical Nutrition (2011) 65, 329-334; doi:10.1038/ejcn.2010.276; published online 12 January 2011