Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus.
Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus.
复制标题
对氧磷酶多态性 (Gln192-Arg) 与日本非胰岛素依赖型糖尿病的冠心病相关。
DOI：
10.1210/jcem.82.7.4096
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
K. Yamashita
中科院分区：
文献类型：
--
作者：
M. Odawara;M. Odawara;Y. Tachi;K. Yamashita
血清对氧磷酶/芳基酯酶（PONA）与高密度脂蛋白有关，可能通过水解脂质过氧化物来阻止低密度脂蛋白的氧化。最近的一份报告显示，在非胰岛素依赖型糖尿病（NIDDM）的高加索患者中，PONA基因192位谷氨酰胺（A型）/精氨酸（B型）多态性与冠心病（CHD）有关。然而，也报道了相互矛盾的结果。为了探讨这种多态性在冠心病发病机制中的意义，我们在日本NIDDM患者中进行了这种多态性与冠心病的相关性研究。我们对164例NIDDM患者、42例冠心病患者和122例非冠心病患者进行了基因分型。其他已知的冠心病危险因素在两组之间是匹配的。42例合并冠心病的糖尿病患者中有41例检测到AB+BB亚型。糖尿病合并冠心病患者B等位基因携带者（AB+BB）比例明显高于非冠心病患者AA等位基因携带者（chi 2 = 7.68, P = 0.003）。多因素logistic回归分析显示，B等位基因携带者的优势比显著增加（OR: 8.823, CI: 1.13 ~ 68.7），其他危险因素的优势比在1.01 ~ 1.92之间。PONA基因Gln192Arg多态性的B等位基因携带者在日本NIDDM患者中患冠心病的风险增加。这种关联与其他已知的冠心病危险因素无关，提示对氧磷酶B异构体在冠心病发病中的重要作用。
Serum paraoxonase/arylesterase (PONA) is associated with high-density lipoprotein and may prevent oxidation of low-density lipoprotein by hydrolyzing lipid peroxides. A recent report suggested an association of glutamine (A type)/arginine (B type) polymorphism at position 192 of PONA gene with coronary heart disease (CHD) among Caucasian patients with noninsulin-dependent diabetes mellitus (NIDDM). However, conflicting results have also been reported. To investigate the significance of this polymorphism in the pathogenesis of CHD, we performed an association study of this polymorphism with CHD in Japanese NIDDM patients. We genotyped 164 patients with NIDDM, 42 with CHD, and 122 without CHD. Other known risk factors for CHD were matched between the 2 groups. AB+BB isoforms were detected in 41 of 42 diabetic patients with CHD. The proportion of B allele carriers (AB+BB) was significantly higher than that of AA carriers among diabetic patients with CHD compared with those without CHD (chi 2 = 7.68, P = 0.003). Multivariate logistic regression analyses showed a markedly increased odds ratio (OR: 8.823, CI, 1.13-68.7) in B allele carriers, while ORs of other risk factors remained between 1.01 and 1.92. Carriers of the B allele of the Gln192Arg polymorphism in the PONA gene proved to be at increased risk for developing CHD in Japanese NIDDM patients. This association was independent of other known risk factors for CHD, suggesting an important role of the paraoxonase B isoform in the pathogenesis of CHD.
影响因子：
5.1
作者：
FURLONG, CE;COSTA, LG;HUMBERT, R
通讯作者：
HUMBERT, R
影响因子：
5.2
作者：
Barbalata, Teodora;Deleanu, Mariana;Stancu, Camelia Sorina
通讯作者：
Stancu, Camelia Sorina