USE OF RECOMBINANT VACCINIA RABIES VIRUS FOR ORAL VACCINATION OF FOX CUBS (VULPES-VULPES, L) AGAINST RABIES
USE OF RECOMBINANT VACCINIA RABIES VIRUS FOR ORAL VACCINATION OF FOX CUBS (VULPES-VULPES, L) AGAINST RABIES
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DOI：
10.1016/0378-1135(88)90055-7
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发表时间：
1988-10-01
影响因子：
3.3
通讯作者：
PASTORET, PP
中科院分区：
文献类型：
--
作者：
BROCHIER, BM;LANGUET, B;PASTORET, PP
13 只狐狸幼崽口服了 107.2 空斑形成单位的活牛痘-狂犬病糖蛋白重组病毒。疫苗接种后第 28 天，除了 1 只幼崽外，所有幼崽都产生了狂犬病病毒抗体。 12只动物在接种后第33天（5只狐狸）、180天（4只狐狸）或360天（3只狐狸）肌内接种103.2小鼠脑内LD50的狂犬病病毒悬浮液。其中 11 人抵抗了狂犬病挑战。未接种疫苗的狐狸，无论是与 1 只接种疫苗的动物接触还是用作对照，在第 33 天进行攻击后均死亡。还证明了该疫苗株不存在水平传播及其对幼崽的无害性。
Thirteen fox cubs were orally administered 107.2 plaque-forming units of live vaccinia-rabies glycoprotein recombinant virus. On Day 28 post-vaccination, all but 1 cub had produced rabies virus antibodies. Twelve animals were intramuscularly inoculated with 103.2 mouse intracerebral LD50 of rabies virus suspension on Days 33 (5 foxes), 180 (4 foxes) or 360 (3 foxes) after vaccination. Eleven of them resisted rabies challenge. Unvaccinated foxes, either put in contact with 1 vaccinated animal or used as controls, died after challenge applied on Day 33. The absence of horizontal transmission of this vaccine strain and its innocuity to cubs were also demonstrated.