IMMUNOHISTOCHEMICAL LOCALIZATION OF EXTRAVASATED SERUM-ALBUMIN IN THE HIPPOCAMPUS OF HUMAN-SUBJECTS WITH PARTIAL AND GENERALIZED EPILEPSIES AND EPILEPTIFORM CONVULSIONS
IMMUNOHISTOCHEMICAL LOCALIZATION OF EXTRAVASATED SERUM-ALBUMIN IN THE HIPPOCAMPUS OF HUMAN-SUBJECTS WITH PARTIAL AND GENERALIZED EPILEPSIES AND EPILEPTIFORM CONVULSIONS
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DOI：
10.1007/bf00689824
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发表时间：
1984-01-01
影响因子：
12.7
通讯作者：
BOZOKY, B
中科院分区：
文献类型：
--
作者：
MIHALY, A;BOZOKY, B
用过氧化物酶-抗过氧化物酶标记法对癫痫患者和正常对照组脑海马组织切片中的人血清白蛋白免疫反应进行检测。癫痫患者海马区可见免疫阳性星形胶质细胞，其数量随癫痫发作程度的加重而增多。在癫痫持续状态下死亡的患者中，免疫反应阳性的星形胶质细胞数量最多。生活中没有神经系统疾病的对照组患者的海马区没有免疫反应星形胶质细胞。根据癫痫发作期间血脑屏障的破坏情况，对结果进行了讨论。
Human serum albumin-like imunoreactivity was detected by the peroxidase-antiperoxidase method in histological sections of the hippocampus from epileptic and control brains obtained on routine autopsies. In the hippocampi of epileptic patients immunoreactive astrocytes were found, the number of which was increasing with the severity of the manifest convulsions. The highest numbers of immunoreactive astrocytes were observed in those patients who died in status epilepticus. Hippocampi from control patients with no neurologic disorders in life were devoid of immunoreactive astrocytes. The results are discussed in terms of the breakdown of the blood-brain barrier during epileptic seizures.