The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control.
The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control.
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SWI/SNF 染色质重塑因子 BAF60a、b 和 c 在营养信号传导和代谢控制中的作用
DOI：
10.1007/s13238-017-0442-2
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发表时间：
2018-03
期刊：
影响因子：
21.1
通讯作者：
Meng ZX
中科院分区：
文献类型：
--
作者：
Wang RR;Pan R;Zhang W;Fu J;Lin JD;Meng ZX
代谢综合征已成为一种全球性流行病，对人类健康产生不利影响。遗传和环境因素都有助于代谢紊乱的发病机制;然而，整合这些线索来调节代谢生理和代谢紊乱的发展的机制仍然不完全确定。新出现的证据表明，SWI/SNF染色质重塑复合物对于指导代谢重编程和适应以响应营养和其他生理信号至关重要。ATP依赖的SWI/SNF染色质重塑复合物由多达11个亚基组成，其中BAF 60亚基是连接核心复合物和特异性转录因子的关键。BAF 60亚基有三个成员，BAF 60 a、B和c。BAF 60蛋白不同的组织分布模式和调节机制赋予每个亚型在不同代谢细胞类型中的专门功能。本文综述了BAF 60蛋白在生理和疾病条件下对营养感受和能量代谢的调控作用及其机制。
Metabolic syndrome has become a global epidemic that adversely affects human health. Both genetic and environmental factors contribute to the pathogenesis of metabolic disorders; however, the mechanisms that integrate these cues to regulate metabolic physiology and the development of metabolic disorders remain incompletely defined. Emerging evidence suggests that SWI/SNF chromatin-remodeling complexes are critical for directing metabolic reprogramming and adaptation in response to nutritional and other physiological signals. The ATP-dependent SWI/SNF chromatin-remodeling complexes comprise up to 11 subunits, among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit has three members, BAF60a, b, and c. The distinct tissue distribution patterns and regulatory mechanisms of BAF60 proteins confer each isoform with specialized functions in different metabolic cell types. In this review, we summarize the emerging roles and mechanisms of BAF60 proteins in the regulation of nutrient sensing and energy metabolism under physiological and disease conditions.
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影响因子：
30.8
作者：
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通讯作者：
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