Insulo-acinar portal system in the horse pancreas.
Insulo-acinar portal system in the horse pancreas.
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马胰腺中的岛腺门系统。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
T. Fujita
中科院分区：
文献类型：
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作者：
T. Fujita
对马的胰腺动脉注射印度墨水。固定后手工制作切片，用水杨酸甲酯清洗，进行光镜观察。每个胰岛接受小叶内动脉的末端分支。这条动脉不直接供应腺泡组织，除了在胰腺较小的无胰岛区域发出稀有的分支断裂。小动脉到达胰岛的中心点，突然破裂成肿胀的毛细血管，延伸到胰岛的外围。在距胰岛边缘一定距离处，细小的传出血管与腺泡组织的毛细血管网相通。因此，马的外分泌胰腺几乎全部通过胰岛获得血液供应，如果不是全部的话。传出血管虽然在结构上是毛细血管，但在功能上可称为“门脉”。它们向外分泌组织传递胰岛激素，这是我们最近从平行研究中了解到的，是外分泌胰腺的促分泌剂。血液从马胰岛中心到胰岛周围的血管通路似乎是有目的的，因为这种动物的胰岛中心聚集的A细胞分泌的胰高血糖素可以在下游的B细胞上发挥胰岛素释放的功能。在有中央B细胞和外周A细胞的兔子身上，血管被设计成将血液从外围引导到中心。
The horse pancreas was arterially injected with India ink. After fixation slices were made by hand and cleared in methyl salicylate for microscopic observation.1. Each islet receives an end branch of the intralobular artery. This artery does not directly supply the acinar tissue, except for issuing rare branches breaking up in smaller, islet-free regions of the pancreas.2. The arteriole reaches a central point of the islet and abruptly breaks up into swollen capillaries which extend to the periphery of the islet.3. Thin efferent vessels radiate to communicate, at a certain distance from the islet margin, with the capillary net of the acinar tissue.4. The horse exocrine pancreas thus receives its blood supply almost entirely, if not exclusively, through the islet. The efferent vessels may functionally be called “portal” though they are capillaries in structure. They convey to the exocrine tissue islet hormones which have recently been learned from our parallel study to be secretagogues to the exocrine pancreas.5. The vascular route leading the blood from the center to the periphery of the islet in the horse seems purposeful, because glucagon issued from the A cells which are gathered in the islet center in this animal can exert its function as an insulin releaser upon the B cells downstream. In the rabbit which has central B cells and peripheral A cells the vessels are designed to lead blood from the periphery to the center.