Impact of sinus surgery on type 2 airway and systemic inflammation in asthma
Impact of sinus surgery on type 2 airway and systemic inflammation in asthma
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DOI：
10.1080/02770903.2020.1729380
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发表时间：
2020-02-18
影响因子：
1.9
通讯作者：
Matsunaga, Kazuto
中科院分区：
文献类型：
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作者：
Hamada, Kazuki;Oishi, Keiji;Matsunaga, Kazuto
目的：哮喘经常与慢性鼻窦炎伴鼻息肉（CRSwNP）相关。尽管内窥镜鼻窦手术 (ESS) 可改善 CRSwNP 哮喘患者的哮喘控制，但手术治疗反应的机制仍不清楚。我们评估了接受 ESS 且哮喘控制不佳的嗜酸性粒细胞 CRSwNP 患者的哮喘控制变化与气道/全身炎症变化的相关性。方法：我们前瞻性评估了 ESS 前 1 周以及 ESS 后 8 周和 52 周的哮喘控制问卷 (ACQ) 评分、血嗜酸性粒细胞计数 (B-Eos)、1 秒用力呼气量 (FEV1) 以及呼出一氧化氮分数 (FeNO) 水平的变化。结果：对 25 名受试者进行了分析。 ESS 后 ACQ 评分、B-Eos 和 FeNO 下降，FEV1 显着增加。从基线到 ESS 后 52 周期间，ACQ 的变化与血液嗜酸性粒细胞计数的变化显着相关（r = 0.58，p
Objective: Asthma is frequently associated with chronic rhinosinusitis with nasal polyps (CRSwNP). Although endoscopic sinus surgery (ESS) improves asthma control in CRSwNP patients with asthma, the mechanism that underlies the response to surgical treatment is still unclear. We evaluated the relevance of changes in asthma control and changes in airway/systemic inflammation in eosinophilic CRSwNP patients with not well controlled asthma who underwent ESS. Methods: We prospectively assessed changes in the asthma control questionnaire (ACQ) score, blood eosinophil counts (B-Eos), forced expiratory volume in 1 s (FEV1), and fraction of exhaled nitric oxide (FeNO) levels at 1-week before and 8 and 52 weeks after ESS. Results: Twenty-five subjects were analyzed. The ACQ score, B-Eos, and FeNO decreased, and FEV1 increased significantly after ESS. In the period from baseline to 52 weeks after ESS, changes in ACQ were significantly correlated with the changes in blood eosinophil counts (r = 0.58, p