The Rb/E2F pathway and cancer
The Rb/E2F pathway and cancer
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DOI：
10.1093/hmg/10.7.699
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发表时间：
2001-04-01
影响因子：
3.5
通讯作者：
Nevins, JR
中科院分区：
文献类型：
--
作者：
Nevins, JR
在过去的十年里，专注于控制细胞增殖机制的研究与同样密集的针对与人类癌症相关的致癌途径的分析的努力汇聚在一起。这些趋同的研究揭示了控制视网膜母细胞瘤肿瘤抑制蛋白(Rb)活性的途径所起的中心作用，Rb反过来调节E2F转录因子。特别是，现在很清楚的是，Rb/E2F通路在调控DNA复制的启动中起着关键作用。很明显，该途径的控制在几乎所有人类癌症中都是被破坏的，然而，关于该途径中的个体活动在控制细胞生长和参与癌症发展中所起的具体作用仍然存在疑问。
Over the past decade, studies focusing on the mechanisms controlling cellular proliferation have converged with equally intensive efforts directed at the analysis of oncogenic pathways associated with human cancer. These convergent studies have revealed the central role played by the pathway that controls the activity of the retinoblastoma tumor suppressor protein (Rb), which in turn regulates the E2F transcription factor. In particular, it is now clear that the Rb/E2F pathway is critical in regulating the initiation of DNA replication. It is also clear that the control of the pathway is disrupted in virtually all human cancers, Questions remain, however, as to the specific role played by individual activities within the pathway in the control of cell growth and their participation in the development of cancer.