A and B and A1Leb Substances in Glycosphingolipid Fractions of Human Serum 1
A and B and A1Leb Substances in Glycosphingolipid Fractions of Human Serum 1
复制标题
人血清 1 的鞘糖脂组分中的 A、B 和 A1Leb 物质
DOI：
10.1111/j.1423-0410.1975.tb02737.x
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发表时间：
1975
期刊：
影响因子：
2.7
通讯作者：
J. Wherrett
中科院分区：
文献类型：
--
作者：
C. Tilley;M. Crookston;B. Brown;J. Wherrett
抽象的。用A、B组和A1、Le(a-b+)供体血清制备的鞘糖脂部分吸附A、B和A1Leb物质到红细胞上。O组细胞与A、B组供者血清制备的组份接触后，与某些O组血清中存在的IgM交叉反应抗体发生凝集反应。细胞暴露于A1、Le(a-b+)血清组分后，用抗A1Leb进行凝集。组分中A物质的含量与A亚型(A1或A2)、供者的Lewis表型和分泌型有关。向脂肪组分中加入全血清会抑制从脂组分中摄取血型物质。
Abstract. A and B and A1Leb substances were adsorbed onto red cells exposed to glycosphingolipid fractions prepared from the serum of group A and B and A1, Le(a‐b+) donors. Group O cells exposed to fractions prepared from the serum of group A or B donors were agglutinated by an IgM cross‐reacting antibody present in some group O sera. Cells exposed to fractions from A1, Le(a‐b+) serum were agglutinated by anti‐A1Leb. The amount of A substance in the fractions was related to the A subtype (A1 or A2) and to the Lewis and secretor phenotype of the donor. The uptake of blood‐group substances from the lipid fractions was inhibited by the addition of whole serum to the fractions.