Regulation of tumor growth and metastasis: the role of tumor microenvironment.
Regulation of tumor growth and metastasis: the role of tumor microenvironment.
复制标题
DOI：
10.4137/cgm.s11285
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Burnouf T
中科院分区：
文献类型：
--
作者：
Goubran HA;Kotb RR;Stakiw J;Emara ME;Burnouf T
具有恶性潜能或肿瘤特征的异常细胞的存在是相对常见的现象。这些异常细胞与其微环境的相互作用对于肿瘤发展、保护免受身体免疫或防御机制的影响、后期进展以及危及生命或转移性疾病的发展至关重要。肿瘤微环境是一个集合术语，包括肿瘤周围和支持性基质、免疫系统的不同效应物、血小板、激素和其他体液因子。更好地了解肿瘤细胞及其微环境之间的相互作用可以为癌症管理提供有效的工具，以及更好的预防，筛查和风险评估方案。
The presence of abnormal cells with malignant potential or neoplastic characteristics is a relatively common phenomenon. The interaction of these abnormal cells with their microenvironment is essential for tumor development, protection from the body’s immune or defence mechanisms, later progression and the development of life-threatening or metastatic disease. The tumor microenvironment is a collective term that includes the tumor’s surrounding and supportive stroma, the different effectors of the immune system, blood platelets, hormones and other humoral factors. A better understanding of the interplay between the tumor cells and its microenvironment can provide efficient tools for cancer management, as well as better prevention, screening and risk assessment protocols.