NOVEL GLYCOSYLATION ROUTES FOR GLYCOPROTEINS - THE LACDINAC PATHWAY
NOVEL GLYCOSYLATION ROUTES FOR GLYCOPROTEINS - THE LACDINAC PATHWAY
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DOI：
10.1042/bst0230175
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发表时间：
1995-02-01
影响因子：
3.9
通讯作者：
VANDIE, I
中科院分区：
文献类型：
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作者：
VANDENEIJNDEN, DH;NEELEMAN, AP;VANDIE, I
蛋白质和脂质连接的复合型寡糖链通常基于GalPl-+ 4GlcNAc（N-乙酰基-乳糖胺，lacNAc）单元，其用作骨架结构元件。然而，在越来越多的情况下，在糖蛋白的N-和0-连接的寡糖链上发现GalNAca 1-+ 4GlcNAc（4”-二乙酰基-乳糖二胺，lacdiNAc）单元而不是lacNAc单元（[1 -241];参见表1）。携带这种链的糖蛋白组是相当多样的，并且阿利亚包括激素、酶、膜糖蛋白和转运蛋白。似乎lacdiNAc型链特别出现在低等动物物种的糖蛋白上，但也沿着lacNAc型链存在于哺乳动物糖蛋白上。与复合型低聚糖结构中的lacNAc单元一样，lacdiNAc单元可以被a2-3-或a2-6-键中的末端NeuAc残基封端[S-121。它们也可能在与GlcNAc的1-+ S键中含有Fuc残基
Protein-and lipid-linked complex-type oligosaccharide chains are commonly based on GalPl-+ 4GlcNAc (N-acetyl-lactosamine, lacNAc) units that serve as backbone structural elements. However, in an increasing number of instances GalNAca 1-+ 4GlcNAc (4”-diacetyl-lactosdiamine, 1acdiNAc) units rather than lacNAc units are found on the N-and 0-linked oligosaccharide chains of glycoproteins ([l-241; see Table 1). The group of glycoproteins that carry such chains is quite diverse and comprises inter alia hormones, enzymes, membrane glycoproteins and transport proteins. It appears that lacdiNAc-type chains particularly occur on glycoproteins of lower animal species, but are also present along with lacNAc-type chains on mammalian glycoproteins. Like the lacNAc unit in complex-type oligosaccharide structures, lacdiNAc units may be capped by terminal NeuAc residues in a2-3-or a2-6-linkage [S-121. They also may contain a Fuc residue in a 1-+ Slinkage to GlcNAc