The contribution of allergen-specific IgG to the development of th2-mediated airway inflammation.
The contribution of allergen-specific IgG to the development of th2-mediated airway inflammation.
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DOI：
10.1155/2012/236075
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Sperling AI
中科院分区：
文献类型：
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作者：
Williams JW;Tjota MY;Sperling AI
在人类哮喘患者和过敏动物模型中，过敏原特异性免疫球蛋白可促进Th2介导的过敏性炎症。小鼠模型已阐明免疫球蛋白和Fc-γ受体(Fc-γR)在抗原提呈细胞上的信号转导在诱导呼吸道炎症中的重要作用。这些研究表明，适应性B细胞反应产生的免疫球蛋白与天然免疫细胞上的FcγR信号之间存在正反馈循环。对哮喘或过敏性肺部疾病患者体内免疫球蛋白和Fcγ受体的研究一直存在较大争议。一些报告已经确定了过敏原特异性免疫球蛋白与过敏反应的严重程度之间的关联，而其他研究发现了免疫球蛋白亚类IgG4与过敏耐受性之间的关联。在本文中，我们回顾文献，以帮助确定免疫球蛋白和FcγR信号在天然免疫细胞上的性质，以及它如何在变态反应的发生中起作用。
In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation. These studies suggest a positive feedback loop between IgG produced by the adaptive B cell response and FcγR signaling on innate immune cells. Studies of IgG and FcγRs in humans with asthma or allergic lung disease have been more controversial. Some reports have identified associations between allergen-specific IgG and severity of allergic responses, while other studies have found associations of IgG subclass IgG4 with allergic tolerance. In this paper, we review the literature to help define the nature of IgG and FcγR signaling on innate immune cells and how it contributes to the development of allergic immune responses.