The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies.
The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies.
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肢体预模式的两域假说及其与先天性肢体异常的相关性。
DOI：
10.1002/wdev.270
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Hopyan,Sevan
中科院分区：
文献类型：
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作者：
Tao,Hirotaka;Kawakami,Yasuhiko;Hui,Chi-Chung;Hopyan,Sevan
基础发育研究可以对导致人体肢体异常的突变进行功能注释。在这项研究中，我们重点关注肢体发育的预模式阶段，并讨论了一个最新的模型，该模型提出早期肢芽的前部和后部区域生成未来骨骼的两半。通过比较人类和模型生物的表型，我们评估了这种预模式化概念是否有助于注释人类疾病等位基因。WIREs Dev Biol2017, 6:e270。 doi: 10.1002/wdev.270本文分类为：脊椎动物器官发生 > 肌肉骨骼和血管出生缺陷 > 器官异常
Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles.WIREs Dev Biol2017, 6:e270. doi: 10.1002/wdev.270This article is categorized under:Vertebrate Organogenesis > Musculoskeletal and VascularBirth Defects > Organ Anomalies