Biofunctionality with a twist: the importance of molecular organisation, handedness and configuration in synthetic biomaterial design.
Biofunctionality with a twist: the importance of molecular organisation, handedness and configuration in synthetic biomaterial design.
复制标题
扭曲的生物功能：分子组织、手性和构型在合成生物材料设计中的重要性。
DOI：
10.1039/d1cs00896j
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发表时间：
2022
影响因子：
46.2
通讯作者：
Hendrikse SIS
中科院分区：
文献类型：
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作者：
Hendrikse SIS
生命的基石——核苷酸、氨基酸和糖类——产生了种类繁多的成分，构成了自然界中发现的层次结构。在手性和非共价相互作用的驱动下，形成了螺旋状和高度组织化的结构，它们折叠的方式与特定的识别和功能相关。大量的努力正在投入到模仿这些高度专业化的生物系统作为生物医学应用的生物材料，从药物发现到再生医学。然而，除了缺乏自然界的复杂性外，它们的生物活性有时也很低，等级秩序缺失或不发达。此外，天然生物分子中折叠的微小差异（例如，由突变引起的）可能对它们的功能产生灾难性的影响。为了开发更有效地与生物分子（如蛋白质、DNA和细胞）相互作用的生物材料，我们推测将顺序和手性纳入生物材料设计是必要的。在这篇综述中，我们首先关注在自然界中发现的多肽、核苷酸和糖的顺序和手性，然后选择基于这些成分的合成仿生系统的例子，旨在捕捉这些有序特征的某些方面。计算模拟在预测原子取向和分子组织方面非常有帮助，并且可以为如何进一步改进生物材料设计提供宝贵的信息。在回顾的最后一部分，提供了一个关键的观点，以及可以在下一代生物材料设计中实施的考虑。
The building blocks of life – nucleotides, amino acids and saccharides – give rise to a large variety of components and make up the hierarchical structures found in Nature. Driven by chirality and non-covalent interactions, helical and highly organised structures are formed and the way in which they fold correlates with specific recognition and hence function. A great amount of effort is being put into mimicking these highly specialised biosystems as biomaterials for biomedical applications, ranging from drug discovery to regenerative medicine. However, as well as lacking the complexity found in Nature, their bio-activity is sometimes low and hierarchical ordering is missing or underdeveloped. Moreover, small differences in folding in natural biomolecules (e.g., caused by mutations) can have a catastrophic effect on the function they perform. In order to develop biomaterials that are more efficient in interacting with biomolecules, such as proteins, DNA and cells, we speculate that incorporating order and handedness into biomaterial design is necessary. In this review, we first focus on order and handedness found in Nature in peptides, nucleotides and saccharides, followed by selected examples of synthetic biomimetic systems based on these components that aim to capture some aspects of these ordered features. Computational simulations are very helpful in predicting atomic orientation and molecular organisation, and can provide invaluable information on how to further improve on biomaterial designs. In the last part of the review, a critical perspective is provided along with considerations that can be implemented in next-generation biomaterial designs.