Therapeutic effects of rapamycin and surgical decompression in a rabbit spinal cord injury model
Therapeutic effects of rapamycin and surgical decompression in a rabbit spinal cord injury model
复制标题
雷帕霉素联合手术减压对兔脊髓损伤模型的治疗作用
DOI：
10.1038/s41419-020-02767-5
复制
发表时间：
2020-07
影响因子：
9
通讯作者：
Li Jianjun
中科院分区：
文献类型：
--
作者：
Zhang Xin;Qin Chuan;Jing Yingli;Yang Degang;Liu Changbin;Gao Feng;Zhang Chao;Talifu Zuliyaer;Yang Mingliang;Du Liangjie;Li Jianjun
Surgical decompression after spinal cord injury (SCI) is a conventional treatment. Although it has been proven to have clinical effects, there are certain limitations, such as the surgical conditions that must be met and the invasive nature of the treatment. Therefore, there is an urgent need to develop a simple and maneuverable therapy for the emergency treatment of patients with SCI before surgery. Rapamycin (RAPA) has been reported to have potential as a therapeutic agent for SCI. In this study, we observed the therapeutic effects of rapamycin and surgical decompression, in combination or separately, on the histopathology in rabbits with SCI. After combination therapy, intramedullary pressure (IMP) decreased significantly, autophagic flux increased, and apoptosis and demyelination were significantly reduced. Compared with RAPA/surgical decompression alone, the combination therapy had a significantly better effect. In addition, we evaluated the effects of mechanical pressure on autophagy after SCI by assessing changes in autophagic initiation, degradation, and flux. Increased IMP after SCI inhibited autophagic degradation and impaired autophagic flux. Decompression improved autophagic flux after SCI. Our findings provide novel evidence of a promising strategy for the treatment of SCI in the future. The combination therapy may effectively improve emergency treatment after SCI and promote the therapeutic effect of decompression. This study also contributes to a better understanding of the effects of mechanical pressure on autophagy after neurotrauma.
登录
查看更多内容
影响因子：
6.1
作者：
Kanno, Haruo;Ozawa, Hiroshi;Itoi, Eiji
通讯作者：
Itoi, Eiji
影响因子：
4.2
作者：
Leonard, Anna V.;Thornton, Emma;Vink, Robert
通讯作者：
Vink, Robert
影响因子：
7.8
作者：
Yamamoto, Ai;Cremona, M Laura;Rothman, James E
通讯作者：
Rothman, James E
影响因子：
3
作者：
Kanno, Haruo;Ozawa, Hiroshi;Itoi, Eiji
通讯作者：
Itoi, Eiji
DOI：
10.1097/01.css.0000499725.56931.10
发表时间：
2016-10
期刊：
Contemporary Spine Surgery
影响因子：
--
作者：
Andre M. Samuel;N. Anandasivam;Pablo J. Diaz-Collado;A. Lukasiewicz;Matthew L. Webb;J. Grauer
通讯作者：
Andre M. Samuel;N. Anandasivam;Pablo J. Diaz-Collado;A. Lukasiewicz;Matthew L. Webb;J. Grauer