Estimating CD4+ cell counts of an individual using population historical data.
Estimating CD4+ cell counts of an individual using population historical data.
复制标题
使用群体历史数据估计个体的 CD4 细胞计数。
DOI:
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发表时间:
2010
期刊:
影响因子:
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通讯作者:
Tsuyoshi Nakamura
中科院分区:
文献类型:
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作者:
T. Makie;N. Ishida;Todd Saunders;Yoshihiko Yamamoto;Tsuyoshi Nakamura
+ cell count; Total lymphocyte count; Sample-based prediction method; Individual-based prediction method; Sensitivity; Predictive-positive rate Abstract Background and objective: WHO guidelines in 2010 no longer recommend the total lymphocyte count (TLC), instead of the CD4 + cell (CD4) count, in deciding on the initiation of anti-retroviral treatment. This is very problematic because of the cost and resources involved in getting CD4 counts. To solve this problem, we developed an efficient and reliable method for predicting CD4 counts based on a previous CD4 count. Subjects and methods: To surmount the degrading of the precision due to the individual variability in CD4 counts, we developed an individual-based prediction method. Results: The sensitivity and the predictive-positive rate of CD4 counts below 350 cells/mm 3 were 89% and 88%, respectively, at a one-month interval and 76% and 84%, respectively, at a six-month interval. Conclusion: The individual-based prediction method of the CD4 count will be useful and critical in resource-poor regions where CD4 counts are not repeatedly available.
DOI:
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发表时间:
2005
期刊:
The American journal of tropical medicine and hygiene.
影响因子:
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作者:
Mwamburi,DMkaya;Ghosh,Mayurika;Fauntleroy,Jim;Gorbach,SherwoodL;Wanke,ChristineA
通讯作者:
Wanke,ChristineA
影响因子:
1
作者:
Kamya,MosesR;Semitala,FredC;Quinn,ThomasC;Ronald,Allan;Njama-Meya,Denise;Mayanja-Kizza,Harriet;Katabira,EllyT;Spacek,LisaA
通讯作者:
Spacek,LisaA