Estimating CD4+ cell counts of an individual using population historical data.

Estimating CD4+ cell counts of an individual using population historical data.
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使用群体历史数据估计个体的 CD4 细胞计数。

DOI:
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发表时间:
2010
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影响因子:
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通讯作者:
Tsuyoshi Nakamura
Tsuyoshi Nakamura
中科院分区:
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文献类型:
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作者:
T. Makie;N. Ishida;Todd Saunders;Yoshihiko Yamamoto;Tsuyoshi Nakamura

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+细胞计数;总淋巴细胞计数;基于样本的预测方法;基于个体的预测方法;敏感性;摘要背景和目的:2010年WHO指南在决定开始抗逆转录病毒治疗时不再推荐使用总淋巴细胞计数(TLC)而不是CD4 +细胞计数(CD4)。这是非常有问题的,因为获得CD4计数所涉及的成本和资源。为了解决这个问题,我们开发了一种高效可靠的方法来预测CD4计数基于先前的CD4计数。对象和方法:为了克服由于CD4计数的个体差异而导致的精度降低,我们开发了一种基于个体的预测方法。结果:CD4计数低于350细胞/mm 3的敏感性和预测阳性率在1个月的间隔时间分别为89%和88%,在6个月的间隔时间分别为76%和84%。结论:基于个体的CD4计数预测方法在不能重复获得CD4计数的资源贫乏地区将是有用和关键的。
+ cell count; Total lymphocyte count; Sample-based prediction method; Individual-based prediction method; Sensitivity; Predictive-positive rate Abstract Background and objective: WHO guidelines in 2010 no longer recommend the total lymphocyte count (TLC), instead of the CD4 + cell (CD4) count, in deciding on the initiation of anti-retroviral treatment. This is very problematic because of the cost and resources involved in getting CD4 counts. To solve this problem, we developed an efficient and reliable method for predicting CD4 counts based on a previous CD4 count. Subjects and methods: To surmount the degrading of the precision due to the individual variability in CD4 counts, we developed an individual-based prediction method. Results: The sensitivity and the predictive-positive rate of CD4 counts below 350 cells/mm 3 were 89% and 88%, respectively, at a one-month interval and 76% and 84%, respectively, at a six-month interval. Conclusion: The individual-based prediction method of the CD4 count will be useful and critical in resource-poor regions where CD4 counts are not repeatedly available.
使用淋巴细胞总数预测 CD4 计数:HAART 使用过程中临床决策的可持续工具。
DOI: --
发表时间: 2005
期刊: The American journal of tropical medicine and hygiene.
影响因子: --
作者:
Mwamburi,DMkaya;Ghosh,Mayurika;Fauntleroy,Jim;Gorbach,SherwoodL;Wanke,ChristineA
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在乌干达坎帕拉的 HIV 患者中,淋巴细胞总数 1200 并不是 CD4 淋巴细胞计数的敏感预测因子。
DOI: --
发表时间: 2004
影响因子: 1
作者:
Kamya,MosesR;Semitala,FredC;Quinn,ThomasC;Ronald,Allan;Njama-Meya,Denise;Mayanja-Kizza,Harriet;Katabira,EllyT;Spacek,LisaA
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