Diurnal blood pressure variation and dietary salt in spontaneously hypertensive rats.
Diurnal blood pressure variation and dietary salt in spontaneously hypertensive rats.
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自发性高血压大鼠的昼夜血压变化和膳食盐。
DOI：
10.1161/01.hyp.24.1.1
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Oparil,S
中科院分区：
文献类型：
--
作者：
Calhoun,DA;Zhu,S;Wyss,JM;Oparil,S
我们以前曾报道，高饮食盐暴露显着增加白天平均动脉压自发性高血压大鼠（SHR），但在血压正常的Wistar-Kyoto（WKY）控制。在本研究中，我们使用遥测监测系统，以评估高饮食盐暴露对SHR和WKY大鼠的平均动脉压和心率的昼夜变化的影响。植入射频换能器后，SHR和WKY大鼠维持高盐（8%）或基础（1%）的饮食。然后使用非线性数据拟合程序分析血液动力学值的昼夜变化。饮食暴露2周后，高盐喂养的SHR的24小时平均动脉压（156 +/- 3 mmHg）显著高于接受基础（135 +/- 2 mmHg）的SHR和接受高盐（100 +/- 2 mmHg）或基础（100 +/- 1 mmHg）饮食的WKY大鼠。节律分析表明，在高盐暴露在SHR的白天和夜间平均动脉压显着增加。在WKY大鼠中，高盐暴露增加夜间平均动脉压，但不增加白天平均动脉压，对24小时平均动脉压没有净效应。高饮食盐暴露显着降低心率在SHR和WKY大鼠，它没有显着改变昼夜血压或心率变化的模式。这些结果表明，WKY大鼠表现出对盐摄入的急性敏感性，但具有足以防止平均动脉压持续升高的代偿机制;这种机制在SHR中缺乏。
We have previously reported that high dietary salt exposure significantly increases daytime mean arterial pressure in spontaneously hypertensive rats (SHR) but not in normotensive Wistar-Kyoto (WKY) controls. In the present study, we used a telemetry monitoring system to evaluate the effects of high dietary salt exposure on diurnal variation of mean arterial pressure and heart rate in SHR and WKY rats. After implantation of a radio frequency transducer, SHR and WKY rats were maintained on either high (8%) or basal (1%) salt diets. Hemodynamic values were then analyzed for diurnal variation with the use of a nonlinear data-fitting program. After 2 weeks of dietary exposure, high salt-fed SHR had significantly greater 24-hour mean arterial pressure (156 +/- 3 mmHg) than SHR receiving basal (135 +/- 2 mmHg) and WKY rats receiving high (100 +/- 2 mmHg) or basal (100 +/- 1 mmHg) salt diets. Rhythm analysis indicated significant increases in both daytime and nighttime mean arterial pressure during high salt exposure in SHR. In WKY rats, high salt exposure increased nighttime but not daytime mean arterial pressure, with no net effect on 24-hour mean arterial pressure. High dietary salt exposure significantly decreased heart rate in both SHR and WKY rats, and it did not significantly alter the pattern of diurnal blood pressure or heart rate variation. These results indicate that WKY rats manifest an acute sensitivity to salt ingestion but have compensatory mechanisms sufficient to prevent sustained increases in mean arterial pressure; such mechanisms are lacking in SHR.