Diversity of gene expression in adenocarcinoma of the lung
Diversity of gene expression in adenocarcinoma of the lung
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DOI：
10.1073/pnas.241500798
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发表时间：
2001-11-20
影响因子：
11.1
通讯作者：
Petersen, I
中科院分区：
文献类型：
--
作者：
Garber, ME;Troyanskaya, OG;Petersen, I
用24,000个基因芯片检测了56例67例人肺肿瘤的基因表达谱。基于基因表达模式的肿瘤细分忠实地概括了肿瘤的形态学分类为鳞状细胞、大细胞、小细胞和腺癌。基因表达模式使腺癌的亚分类成为可能，亚组与肿瘤分化程度以及患者的生存率相关。因此，基因表达分析有望扩展和完善标准病理分析。
The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.