FDG-PET-positive ovarian thecoma with GLUT5 expression: Five cases
FDG-PET-positive ovarian thecoma with GLUT5 expression: Five cases
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DOI：
10.1111/jog.13243
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发表时间：
2017-03-01
影响因子：
1.6
通讯作者：
Fujiwara, Hiroshi
中科院分区：
文献类型：
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作者：
Bono, Yukiko;Mizumoto, Yasunari;Fujiwara, Hiroshi
正电子发射断层扫描(PET)的F-18脱氧葡萄糖(F-18-FDG)可用于检测恶性肿瘤，但良性病变偶尔会有假阳性的F-18-FDG摄取。在这里，我们报告了5例绝经后卵巢实体瘤患者的磁共振成像和F-18-FDG摄取。5例患者的平均年龄为57岁(53-65岁)。F-18-FDG早期标准摄取值平均为5.76(2.2~12.0)，延迟摄取值平均为6.56(2.4~13.8)。在所有5例患者中，手术时冰冻切片诊断为卵巢瘤，行双侧输卵管卵巢切除术。免疫组织化学染色显示瘤组织中有葡萄糖转运蛋白5(GLUT5)表达。此病例显示卵巢肿瘤在正电子发射断层扫描-计算机断层扫描(PET-CT)上有时有阳性的F-18-FDG摄取，提示良性卵巢实体肿瘤患者的PET-CT假阳性需要谨慎。
Positron emission tomography (PET) with fluorodeoxyglucose F18 (F-18-FDG) is useful for detecting malignancies, but benign lesions occasionally have false-positive F-18-FDG uptake. Here, we report the cases of five postmenopausal women with solid ovarian tumors suspected to be ovarian cancer on magnetic resonance imaging and F-18-FDG uptake. Mean age of the five patients was 57 years (range, 53-65 years). Average early standardized uptake value (SUV) of F-18-FDG was 5.76 (range, 2.2-12.0) and delayed SUV was 6.56 (range, 2.4-13.8). In all five patients, frozen section diagnosis at surgery was thecoma, and bilateral salpingo-oophorectomy was performed. On immunohistochemistry, immunoreactive glucose transporter 5 (GLUT5) expression was detected in thecoma tissues. This case shows that thecoma sometimes has positive F-18-FDG uptake on positron emission tomography-computed tomography (PET-CT), indicating the need for caution regarding false-positive PET-CT in patients with benign solid ovarian tumor.