Impact of Past Research Experience on Subsequent Trials: A Caution.
Impact of Past Research Experience on Subsequent Trials: A Caution.
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过去的研究经验对后续试验的影响：警告。
DOI：
10.1164/rccm.201905-0926le
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发表时间：
2020
影响因子：
24.7
通讯作者：
Mitchell,HermanE
中科院分区：
文献类型：
--
作者：
Villarreal,MiguelA;Wildfire,JeremyJ;Sorkness,ChristineA;Gergen,PeterJ;Visness,CynthiaM;Mitchell,HermanE
结论循环血浆生物标志物是人体内最容易测量的生物标志物之一。在IPF中出现了丰富的生物标志物数据，我们的研究结果表明，进行性IPF的分子标志物实际上可能是进行性PF的标志物，而与ILD亚型无关。需要进一步的研究来验证这些发现，并确定这些生物标志物如何为不同形式的ILD的临床决策提供信息。
ConclusionsCirculating plasma biomarkers are among the most readily measurable biomarkers in the human body. A wealth of biomarker data have emerged in IPF, and our findings suggest that molecular markers of progressive IPF may in fact be markers of progressive PF, irrespective of ILD subtype. Additional research is needed to validate these findings and determine how such biomarkers can inform clinical decision-making across diverse forms of ILD.■