Creating the gene ontology resource: Design and implementation
Creating the gene ontology resource: Design and implementation
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DOI：
10.1101/gr.180801
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发表时间：
2001-08-01
期刊：
影响因子：
7
通讯作者：
Yoon, J
中科院分区：
文献类型：
--
作者：
Ashburner, M;Ball, CA;Yoon, J
可获取的生物信息量呈指数级增长，导致围绕基因及其产物的分子信息注释出现了各种不同的声音。基因本体论（GO）项目旨在为特定的生物领域提供一套结构化的词汇表，可用于描述任何生物体中的基因产物。这项工作包括构建三个广泛的本体论来描述分子功能、生物过程和细胞组分，并提供一个社区数据库资源以支持这些本体论的使用。基因本体论联盟由与三个模式生物数据库相关的科学家发起：SGD（酿酒酵母基因组数据库）、FlyBase（果蝇基因组数据库）和MGD/GXD（小鼠基因组信息学数据库）。其他模式生物数据库小组也正在加入该项目。这些模式生物信息系统中的每一个都在使用基因本体论词汇术语对基因和基因产物进行注释，并将这些注释纳入各自的模式生物数据库中。每个数据库都将其注释文件贡献给一个共享的基因本体论数据资源，公众可在http://www.geneontology.org/访问该资源。基因本体论网站可供社区用于获取基因本体论词汇表以及访问来自模式生物数据库的带注释的基因产物数据集。基因本体论联盟支持基因本体论数据库资源的开发，并提供工具使编目人员和研究人员能够查询和操作这些词汇表。我们相信，这种分子注释资源的共享开发将有助于生物信息的统一。
The exponential growth in the volume of accessible biological information has generated a confusion of voices surrounding the annotation of molecular information about genes and their products. The Gene Ontology (GO) project seeks to provide a set of structured vocabularies for specific biological domains that can be used to describe gene products in any organism. This work includes building three extensive ontologies to describe molecular function, biological process, and cellular component, and providing a community database resource that Supports the use of these ontologies. The GO Consortium was initiated by scientists associated with three model organism databases: SGD, the Saccharomyces Genome database; FlyBase, the Drosophila genome database; and MGD/GXD, the Mouse Genome Informatics databases. Additional model organism database groups are joining the project. Each of these model organism information systems is annotating genes and gene products using GO vocabulary terms and incorporating these annotations into their respective model organism databases. Each database contributes its annotation files to a shared GO data resource accessible to the public at http://www.geneontology.org/. The GO site can be used by the community both to recover the GO vocabularies and to access the annotated gene product data sets from the model organism databases. The GO Consortium supports the development of the GO database resource and provides tools enabling curators and researchers to query and manipulate the vocabularies. We believe that the shared development of this molecular annotation resource will contribute to the unification of biological information.