Frailty predicts severe postoperative complications after elective colorectal surgery
Frailty predicts severe postoperative complications after elective colorectal surgery
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DOI：
10.1016/j.amjsurg.2018.07.009
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发表时间：
2019-04-01
影响因子：
3
通讯作者：
Takamori, Hiroshi
中科院分区：
文献类型：
--
作者：
Okabe, Hirohisa;Ohsaki, Takayuki;Takamori, Hiroshi
背景：我们的目的是阐明虚弱是否会影响择期结直肠手术的严重术后并发症。方法：连续纳入 269 名 65 岁以上接受根治性手术的结直肠癌患者。评估了虚弱和肌肉减少症与术后结果的相关性。临床衰弱 (CF) 定义为临床衰弱量表 (CFS) >= 4。通过使用计算机断层扫描测量骨骼肌面积来评估肌少症。结果：78 名患者 (29%) 患有 CF，159 名患者 (59%) 患有肌少症。 CF 与年龄较大 (P = 0.0008)、术后严重并发症 (P = 0.001) 和术后住院时间 (P < 0.0001) 显着相关，但肌少症则不然。 Logistic 回归分析显示，低位前切除术和 CF 是严重术后并发症的独立预测因子（分别为 P = 0.038 和 P = 0.001）。 结论：CF（而非肌少症）是结直肠癌患者严重术后并发症的稳健预测因子。 (C) 2018 年由爱思唯尔公司出版
Background: We aim to clarify if frailty affects severe postoperative complications in elective colorectal surgery.Methods: Consecutive 269 colorectal cancer patients older than 65 years undergoing curative surgery were enrolled in this study. The relevance of the frailty and sarcopenia to postoperative outcome was assessed. Clinical frailty (CF) was defined as clinical frailty scale (CFS) >= 4. Sarcopenia was assessed by measuring skeletal muscle area using computed tomography.Results: Seventy-eight patients (29%) had CF and 159 patients (59%) had sarcopenia. CF was significantly associated with older age (P = 0.0008), postoperative severe complications (P = 0.001), and postoperative in-hospital stay (P < 0.0001), although sarcopenia was not. Logistic regression analysis revealed that low anterior resection and CF were independent predictors of severe postoperative complications (P = 0.038 and P = 0.001, respectively).Conclusion: CF, but not sarcopenia, is a robust predictor of severe postoperative complications in patients with colorectal cancer. (C) 2018 Published by Elsevier Inc.