Cognitive function in unaffected twins discordant for affective disorder
Cognitive function in unaffected twins discordant for affective disorder
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未受影响双胞胎的认知功能与情感障碍不一致
DOI：
10.1017/s0033291706007896
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发表时间：
2006-08-01
影响因子：
6.9
通讯作者：
Kessing, Lars Vedel
中科院分区：
文献类型：
--
作者：
Christensen, Maj Vinberg;Kyvik, Kirsten Ohm;Kessing, Lars Vedel
背景。患者可能在情感障碍的正常阶段出现认知障碍，但尚不清楚这种障碍在疾病发作前是否普遍存在。本研究的目的是检验情感障碍的遗传倾向与认知障碍相关的假设。方法。在一项横断面高风险病例对照研究中，通过全国登记册确定了有（高风险双胞胎）和没有（对照组/低风险双胞胎）情感障碍病史的健康同卵（MZ）和异卵（DZ）双胞胎。比较了 203 名高风险和低风险双胞胎的认知表现。结果。患有单相情感障碍的健康双胞胎在几乎所有认知功能指标上都表现出较低的表现：选择性和持续注意力、执行功能、语言处理以及工作和陈述性记忆，以及在对人口统计学变量、亚临床症状和轻微精神病理学进行调整后。在对上述协变量进行调整后，双相情感障碍不一致的健康双胞胎在测量情景记忆和工作记忆的测试中表现出较低的表现。发现的离散认知障碍似乎与遗传倾向有关，因为同卵双胞胎在选择性和持续注意力、执行功能、语言处理以及工作和陈述性记忆方面表现出显着的损伤，而同卵双胞胎仅在语言处理和情景记忆方面表现出明显较低的分数。结论。离散认知障碍在情感障碍发作之前就存在并且是遗传性的这一假设得到了支持。因此，认知功能可能是情感障碍的候选内表型。
Background. Patients may present with cognitive impairment in the euthymic phase of affective disorder, but it is unclear whether the impairment is prevalent before onset of the illness. The aim of the present study was to examine the hypothesis that genetic liability to affective disorder is associated with cognitive impairment.Method. In a cross-sectional high-risk case-control study, healthy monozygotic (MZ) and dizygotic (DZ) twins with (High-Risk twins) and without (the control group/Low-Risk twins) a co-twin history of affective disorder were identified through nationwide registers. Cognitive performance of 203 High-Risk and Low-Risk twins was compared.Results. Healthy twins discordant for unipolar disorder showed lower performance on almost all measures of cognitive function: selective and sustained attention, executive function, language processing and working and declarative memory, and also after adjustment for demographic variables, subclinical symptoms and minor psychopathology. Healthy twins discordant for bipolar disorder showed lower performance on tests measuring episodic and working memory, also after adjustment for the above-mentioned covariables. The discrete cognitive impairment found seemed to be related to genetic liability, as the MZ High-Risk twins showed significant impairment on selective and sustained attention, executive function, language processing and working and declarative memory, whereas the DZ High-Risk twins presented with significantly lower scores only on language processing and episodic memory.Conclusions. The hypothesis that discrete cognitive impairment is present before the onset of the affective disorder and is genetically transmitted was supported. Thus, cognitive function may be a candidate endophenotype for affective disorders.