Study Design and Baseline Profiles of Participants in the Uonuma CKD Cohort Study in Niigata, Japan
Study Design and Baseline Profiles of Participants in the Uonuma CKD Cohort Study in Niigata, Japan
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DOI：
10.2188/jea.je20180220
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发表时间：
2020-04-01
影响因子：
4.7
通讯作者：
Narita, Ichiei
中科院分区：
文献类型：
--
作者：
Kabasawa, Keiko;Tanaka, Junta;Narita, Ichiei
Background: Evidence for primary prevention of chronic kidney disease (CKD) is insufficient. The population-based prospective Uonuma CKD cohort study aims to explore associations of lifestyle and other risk factors with CKD. We report here the study design and baseline profiles.Methods: All 67,322 residents aged >= 40 years in Minamiuonuma City, Uonuma City, and Yuzawa Town, Niigata Prefecture, Japan and 11,406 participants who attended local health-check examinations were targeted for baseline questionnaire and biochemical sampling, respectively. Information was gathered from 43,217 (64.2%) questionnaires and 8,052 (70.6%) biochemical samples; 6,945 participants consented to both questionnaire and biochemical sampling at baseline, conducted between fiscal years 2012 and 2015. Participants provided information regarding sociodemographic, lifestyle, and self-reported outcomes. Urine albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured. The primary outcome is CKD based on self-report and biochemical/clinical diagnosis.Results: Mean age of questionnaire respondents was 63.3 (standard deviation [SD], 12.5) years for men and 64.3 (SD, 13.3) years for women. Among participants who submitted urine samples, median ACR was 10.0 (interquartile range [IQR], 5.0-24.0) mg/g for men and 13.0 (IQR, 7.7-27.0) mg/g for women, and median eGFR was 73.6mL/min/1.73m(2) (IQR, 63.5-84.5) for men and 73.5mL/min/1.73m(2) (IQR, 64.4-83.5) for women. ACR 30mg/g or more was found in 1,741 participants (21.7%) and eGFR
