Linker-Mediated Phase Behavior of DNA-Coated Colloids
Linker-Mediated Phase Behavior of DNA-Coated Colloids
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DOI：
10.1103/physrevx.9.041054
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发表时间：
2019-12-13
影响因子：
12.5
通讯作者：
Rogers, W. Benjamin
中科院分区：
文献类型：
--
作者：
Lowensohn, Janna;Oyarzun, Bernardo;Rogers, W. Benjamin
纳米技术研究的一个中心目标是，有可能规定纳米和微观组分之间的局部相互作用，从而指导它们以可预测的方式组装。在本文中，我们提出了一种新的范例，其中dna功能化胶体粒子的自组装是利用连接体寡核苷酸分散在溶液中的编程。我们发现，与通过直接杂交相互作用的其他dna功能化胶体颗粒的典型相图相比，相图惊人地丰富，包括在增加连接剂浓度时的可重入熔融转变，并表明多种连接剂可以同时组合以规定许多相互作用。一种新的理论在不需要任何拟合参数的情况下定量预测所观察到的相行为。综上所述，这些实验和模型为可编程自组装的未来研究奠定了基础，使编程所需的数百种特定相互作用成为可能，以组装完全可寻址的介观结构，同时也扩展了我们对胶体悬浮液中可能的独特相行为的基本理解。
The possibility of prescribing local interactions between nano- and microscopic components that direct them to assemble in a predictable fashion is a central goal of nanotechnology research. In this article, we advance a new paradigm in which the self-assembly of DNA-functionalized colloidal particles is programmed using linker oligonucleotides dispersed in solution. We find a phase diagram that is surprisingly rich compared to phase diagrams typical of other DNA-functionalized colloidal particles that interact by direct hybridization, including a reentrant melting transition upon increasing linker concentration, and show that multiple linker species can be combined to prescribe many interactions simultaneously. A new theory predicts the observed phase behavior quantitatively without any fitting parameters. Taken together, these experiments and model lay the groundwork for future research in programmable self-assembly, enabling the possibility of programming the hundreds of specific interactions needed to assemble fully addressable, mesoscopic structures, while also expanding our fundamental understanding of the unique phase behavior possible in colloidal suspensions.