Treatment of diaphragmatic dystonia with pallidal deep brain stimulation.
Treatment of diaphragmatic dystonia with pallidal deep brain stimulation.
复制标题
用苍白球深部脑刺激治疗膈肌肌张力障碍。
DOI：
10.1136/bcr-2020-240510
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发表时间：
2021
期刊：
影响因子：
0.9
通讯作者：
Mitchell,KyleT
中科院分区：
文献类型：
--
作者：
Rahimpour,Shervin;Calakos,Nicole;Turner,DennisA;Mitchell,KyleT
我们提出的情况下，70岁的妇女与治疗难治性肌张力障碍。患者最初表现为眼睑痉挛，随后在讲话时出现不自主吸气痉挛。她的症状是药物难治性的，因此她接受了清醒的双侧苍白球脑深部电刺激与微电极记录。未发生术中或术后并发症或不良事件，也未出现不良刺激效应。使用双侧背侧苍白球内侧和腹侧苍白球外侧的接触，症状在2-4周的潜伏期后缓解。在5个月随访时，患者的Burke-Fahn-Marsden运动量表评分降低16.5分（从20/120降至3.5/120），眼睑痉挛、不规则吸气以及言语中断和不规则消失。
We present the case of a 70-year-old woman with treatment-refractory diaphragmatic dystonia. Patient initially presented with blepharospasms followed by development of involuntary inspiratory spasms during speech. Her symptoms were drug-refractory, and she therefore underwent awake bilateral pallidal deep brain stimulation with microelectrode recording. No intraoperative or postoperative complications or adverse events occurred, and there were no undesired effects of stimulation. Using contacts in bilateral dorsal globus pallidus interna and ventral globus pallidus externa, symptoms alleviated after a latency period of 2–4 weeks. At 5-month follow-up, the patient maintained a 16.5-point reduction in Burke-Fahn-Marsden movement scale (from 20/120 to 3.5/120) with resolution of blepharospasm, irregular inspirations and broken and irregular speech.