Low body temperature in long-lived Ames dwarf mice at rest and during stress
Low body temperature in long-lived Ames dwarf mice at rest and during stress
复制标题
DOI：
10.1016/s0031-9384(99)00098-0
复制
发表时间：
1999-09-01
影响因子：
2.9
通讯作者：
Meliska, CJ
中科院分区：
文献类型：
--
作者：
Hunter, WS;Croson, WB;Meliska, CJ
在恒温动物中，较大的物种通常比较小的物种具有较低的代谢率和较长的寿命。因为艾姆斯侏儒小鼠（侏儒）比它们的性别和年龄匹配的较大的正常兄弟姐妹（正常人）多活大约1年，我们假设它们具有较低的身体核心温度（T-co）。因此，我们测量了6名侏儒和6名正常人在24小时自由进食，24小时食物剥夺，抗情绪应激的笼子转换期间的T-co。自由采食，T-CO的侏儒平均1.6摄氏度低于正常人;在食物剥夺，T-CO的侏儒和对照组显着低于食物自由采食时;和笼开关后，T-CO升高，在两组。然而，在所有三个实验中，侏儒的T-co明显低于正常人。这些数据支持这样的假设：艾姆斯侏儒小鼠比正常大小的对照小鼠寿命更长，保持比正常小鼠更低的T-co。由于侏儒缺乏促甲状腺激素（TSH）和生长激素（GH），他们的低T-co可能是由于缺乏这些激素导致产热减少的结果。然而，低T-co本身是否与侏儒小鼠的寿命增加有关仍然是一个有趣的可能性有待研究。(C)1999 Elsevier Science Inc.
Among homeothermic animals, larger species generally have lower metabolic rates and live longer than do smaller species. Because Ames dwarf mice (dwarfs) live approximately 1 year longer than their larger normal sex- and age-matched siblings (normals), we hypothesized that they would have lower body core temperature (T-co). We, therefore, measured T-co of six dwarfs and six normals during 24-h periods of ad lib feeding, 24-h food deprivation, anti emotional stress induced by cage switching. With ad lib feeding, T-co of dwarfs averaged 1.6 degrees C lower than normals; during food deprivation, T-co of both dwarfs and controls was significantly lower than when food was available ad lib; and following cage switch, T-co was elevated in both groups. However, during all three experiments, T-co was significantly lower in dwarfs than in normals. These data support the hypothesis that Ames dwarf mice, which live longer than normal size controls, maintain lower T-co than normals. Because dwarfs are deficient in thyroid stimulating hormone (TSH) and growth hormone (GH), their low T-co may be a result of reduced thermogenesis due to lack of those hormones. However, whether low T-co per se is related to the increased longevity of the dwarf mice remains an interesting possibility to be investigated. (C) 1999 Elsevier Science Inc.