There Is More to Wounds than Bacteria: Fungal Biofilms in Chronic Wounds
There Is More to Wounds than Bacteria: Fungal Biofilms in Chronic Wounds
复制标题
DOI：
10.1007/s40588-022-00187-x
复制
发表时间：
2023-01
影响因子：
5.2
通讯作者：
B. Short;A. Bakri;Abdullah Baz;Craig Williams;Jason L. Brown;G. Ramage
中科院分区：
文献类型：
--
作者：
B. Short;A. Bakri;Abdullah Baz;Craig Williams;Jason L. Brown;G. Ramage
综述目的慢性伤口是一种使人衰弱的疾病，其管理对医疗保健专业人员提出了相当大的挑战，并给服务带来了沉重的负担。当这些伤口暴露在外部环境中时，它们容易受到微生物感染，这进一步使其管理复杂化并使临床outcomes.Recent FindingsBacteria通常作为生物膜的一部分存在于伤口中，该生物膜通常是多微生物的性质，以及被描述为对抗菌剂和防腐剂更具毒性和耐受性的细菌和真菌。尽管先进的知识在多微生物生物膜伤口感染方面的细菌，真菌的作用在很大程度上被忽视，其影响慢性和临床管理是不完全赞赏或understanding.SummaryThe的目的是探讨慢性伤口环境中的真菌的意义，并在这样做，了解在伤口管理中的界间相互作用的重要性。
Purpose of ReviewThe management of chronic wounds, a debilitating condition, presents a considerable challenge to healthcare professionals and a significant burden on services. When these wounds are exposed to the external environment, they are susceptible to microbial infection, which further complicates their management and worsens clinical outcomes.Recent FindingsBacteria typically exist in wounds as part of a biofilm, which is often polymicrobial in nature, alongside bacteria and fungi that are described as being more virulent and tolerant towards antimicrobials and antiseptics. Despite advancing knowledge in polymicrobial biofilm wound infections with respect to bacteria, the role of fungi is largely ignored, and their influence in chronicity and clinical management is not fully appreciated or understood.SummaryThe purpose of this review is to explore the significance of fungi within chronic wound environments and, in doing so, understand the importance of interkingdom interactions in wound management.