Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases.
Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases.
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DOI：
10.1172/jci14794
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
M. Hermiston;Zheng Xu;R. Majeti;A. Weiss
中科院分区：
文献类型：
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作者：
M. Hermiston;Zheng Xu;R. Majeti;A. Weiss
蛋白酪氨酸磷酸化的动态调控对细胞生长、分化、迁移和死亡等一系列细胞过程至关重要。因此，它代表了将环境信号整合到细胞反应中的一个强大的控制点。酪氨酸磷酸化的调控由蛋白酪氨酸激酶（PTKs）和蛋白酪氨酸磷酸酶（PTPs）之间的平衡决定。在免疫系统中，这种平衡的精确和协调调节允许对外来抗原的快速反应，而ptk和PTPs之间的不平衡可能导致病理后果，包括自身免疫、免疫缺陷和恶性肿瘤(1)。在这篇综述中，我们重点介绍了在静息T细胞、T细胞活化和免疫反应下调过程中，关键PTKs和PTPs在调节细胞磷酸化酪氨酸水平中发挥关键作用的最新进展。
The dynamic regulation of protein tyrosine phosphorylation is crucial for a number of cellular processes including cell growth, differentiation, migration, and death. It thus represents a powerful control point for integration of environmental signals into cellular responses. Regulation of tyrosine phosphorylation is determined by the balance between protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). In the immune system, precise and coordinated regulation of this equilibrium allows for rapid responses to foreign antigens, whereas an imbalance between PTKs and PTPs can have pathologic consequences, including autoimmunity, immunodeficiency, and malignancy (1). In this review, we highlight recent advances in our understanding of key PTKs and PTPs that play critical roles in modulating cellular levels of phosphotyrosine in resting T cells, during T cell activation, and during downregulation of an immune response.