Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9.
Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9.
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DOI：
10.1016/j.tcb.2016.11.001
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发表时间：
2017-03
影响因子：
19
通讯作者：
Schmid SL
中科院分区：
文献类型：
--
作者：
Bendris N;Schmid SL
分选连接蛋白9（SNX9）是最早发现的一种参与网格蛋白介导的内吞作用的内吞辅助蛋白。然而，最近的数据表明SNX 9是一种多功能支架，可以协调膜运输和重塑与肌动蛋白动力学的变化，以影响不同的细胞过程。在这里，我们回顾了SNX9的积累知识，重点是最近确定的网格蛋白独立的内吞途径，细胞侵袭和细胞分裂，这对SNX9在人类疾病，包括癌症中的功能有影响的作用。
Sorting nexin 9 (SNX9) was first discovered as an endocytic accessory protein involved in clathrin-mediated endocytosis. However, recent data suggest that SNX9 is a multifunctional scaffold that coordinates membrane trafficking and remodeling with changes in actin dynamics to affect diverse cellular processes. Here we review the accumulated knowledge on SNX9 with an emphasis on its recently identified roles in clathrin-independent endocytic pathways, cell invasion and cell division, which have implications for SNX9 function in human disease, including cancer.