Spatial Learning Based on Boundaries in Rats Is Hippocampus-Dependent and Prone to Overshadowing
Spatial Learning Based on Boundaries in Rats Is Hippocampus-Dependent and Prone to Overshadowing
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DOI：
10.1037/a0020824
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发表时间：
2010-10-01
影响因子：
1.9
通讯作者：
Pearce, John M.
中科院分区：
文献类型：
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作者：
Horne, Murray R.;Iordanova, Mihaela D.;Pearce, John M.
在三个实验中，大鼠被要求参考圆形游泳池的边界来寻找水下平台。在第一个实验中，海马体受损的大鼠在寻找隐藏的平台时受到损害，支持以下假设：学习找到某个方向和距离边界的目标取决于海马体，实验2和实验3提供了初步测试，以了解这种边界学习是否偶然发生，无论是否存在与此提议相反的可靠地标。悬挂在平台上方的地标成功地限制了关于平台相对于竞技场边界的位置的学习。讨论探索了海马体编码边界信息的能力，以及基于联想学习框架解释行为结果
In three experiments, rats were required to find a submerged platform by referring to the boundaries of a circular swimming pool In the first experiment, rats with lesions of the hippocampus were impaired at finding the hidden platform, lending support for the proposal that learning to find a goal that is a certain direction and distance from a boundary is dependent upon the hippocampus Experiments 2 and 3 offered preliminary tests to see if such boundary learning occurred Incidentally, irrespective of the presence of a reliable landmark In contrast to this proposal. a landmark hanging above the platform successfully restricted learning about the location of the platform with respect to the boundary of the arena The discussion explores the capacity of the hippocampus to encode boundary information, as well as interprets the behavioral results on the basis of an associative learning framework