Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization
Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization
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DOI：
10.1126/science.1139158
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发表时间：
2007-07-06
期刊：
影响因子：
56.9
通讯作者：
Rokhsar, Daniel S.
中科院分区：
文献类型：
--
作者：
Putnam, Nicholas H.;Srivastava, Mansi;Rokhsar, Daniel S.
海葵是看似原始的动物，与珊瑚、水母和水螅一起构成了最古老的真后生动物门——刺胞动物门。在这里，我们报告了对新兴刺胞动物模型——小星海葵 Nematostella vectensis 基因组草图的比较分析。海葵基因组很复杂，其基因库、外显子-内含子结构和大规模基因连锁更类似于脊椎动物，而不是苍蝇或线虫，这意味着真后生动物祖先的基因组也同样复杂。近五分之一的祖先推断基因是真后生动物的新奇基因，这些基因丰富了细胞信号传导、粘附和突触传递等动物功能。对不同途径的分析表明，沿着导致动物的谱系的这些基因“发明”可能已经与真后生动物祖先中预先存在的真核基因很好地整合。
Sea anemones are seemingly primitive animals that, along with corals, jellyfish, and hydras, constitute the oldest eumetazoan phylum, the Cnidaria. Here, we report a comparative analysis of the draft genome of an emerging cnidarian model, the starlet sea anemone Nematostella vectensis. The sea anemone genome is complex, with a gene repertoire, exon-intron structure, and large-scale gene linkage more similar to vertebrates than to flies or nematodes, implying that the genome of the eumetazoan ancestor was similarly complex. Nearly one-fifth of the inferred genes of the ancestor are eumetazoan novelties, which are enriched for animal functions like cell signaling, adhesion, and synaptic transmission. Analysis of diverse pathways suggests that these gene "inventions" along the lineage leading to animals were likely already well integrated with preexisting eukaryotic genes in the eumetazoan progenitor.