Plasma cell generation during T-cell-dependent immune responses
Plasma cell generation during T-cell-dependent immune responses
复制标题
T 细胞依赖性免疫反应过程中浆细胞的生成
DOI：
10.1093/intimm/dxab071
复制
发表时间：
2021
影响因子：
4.4
通讯作者：
Kurosaki Tomohiro
中科院分区：
文献类型：
--
作者：
Ise Wataru;Kurosaki Tomohiro
浆细胞由活化的 B 细胞最终分化而来，专门用于分泌抗体，抗体是体液免疫中中和入侵病原体的重要效应分子。在受到 T 细胞依赖性抗原攻击后，浆细胞可以在初级滤泡外反应、生发中心 (GC) 反应或次级记忆反应过程中产生。最近的研究表明，浆细胞的生成不仅受到几个关键转录因子的调节，还受到表观遗传修饰的调节。此外，GC B 细胞向浆细胞命运的分化与对抗原的亲和力有关，并由与滤泡辅助 T 细胞的接触强度决定。
Plasma cells are terminally differentiated from activated B cells and are specialized for secreting antibodies, which are essential effector molecules in humoral immunity to neutralize invading pathogens. Upon challenge with T-cell-dependent antigens, plasma cells can be generated during the primary extrafollicular response, the germinal center (GC) response or the secondary memory response. Recent studies have revealed that plasma cell generation is regulated not only by several key transcription factors but also by epigenetic modifications. In addition, the differentiation of GC B cells toward a plasma cell fate is associated with affinity for antigens and is determined by the strength of contact with T follicular helper cells.