A PET STUDY OF WORD FINDING
A PET STUDY OF WORD FINDING
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DOI：
10.1016/0028-3932(91)90029-8
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发表时间：
1991-01-01
期刊：
影响因子：
2.6
通讯作者：
FRACKOWIAK, RSJ
中科院分区：
文献类型：
--
作者：
FRITH, CD;FRISTON, KJ;FRACKOWIAK, RSJ
我们已经使用PET结合心理激活来识别参与单词表征内在激活的皮层区域。在四个正常受试者的内在生成一个词（言语流畅性）与左背外侧前额叶皮层活动（BA 46）的增加和听觉和上级颞叶皮层活动的双边减少。相反，当被试对听到的单词进行词汇判断时，上级颞叶活动增加，而46区没有变化。我们认为，上级颞叶区是储存单词表征的场所，左前额叶皮层对这些区域的抑制性调制是内在单词生成的基础。
We have used PET in conjunction with psychological activations to identify cortical areas involved in the intrinsic activation of word representations. In four normal subjects intrinsic generation of a word (verbal fluency) was associated with an increase in left dorsolateral prefrontal cortical activity (BA 46) and a bilateral decrease in activity in auditory and superior temporal cortices. Conversely, when subjects made lexical decisions about words that were heard, there was an increase in superior temporal activity with no change in area 46.We suggest that the superior temporal regions are the site of stored word representations and that inhibitory modulation of these areas by the left prefrontal cortex is the basis of intrinsic word generation.