The role of early expression of inducible nitric oxide synthase in human breast cancer
The role of early expression of inducible nitric oxide synthase in human breast cancer
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DOI：
10.1016/j.ejca.2004.07.010
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发表时间：
2005-01-01
影响因子：
8.4
通讯作者：
Kauffmann, M
中科院分区：
文献类型：
--
作者：
Loibl, S;Buck, A;Kauffmann, M
一氧化氮合酶在乳腺癌中表达。为了阐明诱导型一氧化氮合酶 (i-NOS) 在人类乳腺癌中的临床作用，对 161 个原发性乳腺癌组织进行了免疫组织化学染色。 i-NOS 的染色模式与经典预后因素相关，例如淋巴结状态、年龄、激素受体状态、肿瘤大小和肿瘤分化。具有经典的预后因素，如淋巴结状态、年龄、激素受体状态、肿瘤大小和肿瘤分化。还分析了患者的生存情况。百分之六十一的肿瘤 i-NOS 染色呈阳性。 i-NOS 的检测与肿瘤大小的增加和肿瘤分化的减少呈正相关（分别为 P = 0.018 和 P = 0.039）。然而，在小于或等于50岁年龄组中，i-NOS染色也与淋巴结状态相关。与染色阴性的乳腺癌患者相比，i-NOS 阳性乳腺癌患者的总生存率显着较差（5 年生存率分别为 84.8% 和 67.1%；P = 0.049；对数秩检验）。迄今为止，这是对乳腺癌患者 i-NOS 表达最大规模的分析，也是唯一评估生存率的研究。 (C) 2004 Elsevier Ltd. 保留所有权利。
Nitric oxide synthases are expressed in breast cancer. To elucidate the clinical role of the inducible NOS (i-NOS) in human breast cancer, 161 primary breast cancer tissues were stained immunohistochemically. Staining patterns for i-NOS were correlated with classical prognostic factors such as lymph node status, age, hormonal receptor status, tumour size and tumour differentiation. With classical prognostic factors such as lymph node status, age, hormonal receptor status, tumour size and tumour differentiation. Patients survival was also analysed. Sixty-one percent of the tumours stained positively for i-NOS. Detection of i-NOS was positively correlated with increasing tumour size and decreasing tumour differentiation (P = 0.018 and P = 0.039, respectively). However, in the less than or equal to50 year age group, i-NOS staining also correlated with lymph node status. Patients with i-NOS-positive breast carcinomas had a significantly worse overall survival rate versus those with negative stains (5-year survival rate 84.8% versus 67.1%; P = 0.049; log-rank test). To date, this is the largest analysis of i-NOS expression in breast cancer patients and the only study to assess survival. (C) 2004 Elsevier Ltd. All rights reserved.