Functional antagonism of airway constriction in the canine lung periphery.
Functional antagonism of airway constriction in the canine lung periphery.
复制标题
犬肺周边气道收缩的功能拮抗作用。
DOI：
10.1152/jappl.1991.71.5.1848
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Freed,AN
中科院分区：
文献类型：
--
作者：
Lindeman,KS;Hirshman,CA;Freed,AN
我们研究了β-肾上腺素能激动剂（沙丁胺醇）在麻醉的杂种犬和Basenji Greyhound（BG）犬的肺外周中减弱钙螯合剂和乙酰胆碱诱导的气道收缩的能力。使用楔形支气管镜技术测量雾化Na 2 EDTA和乙酰胆碱激发前后的侧支系统阻力。对Na 2 EDTA的反应的时间过程在杂种犬和BG犬之间存在显著差异。对4% Na 2 EDTA激发的峰值反应出现在杂种犬的2 min内，BG犬的5 min内。在两组动物中，沙丁胺醇（1 μ g/kg iv）显著减弱了Na 2 EDTA诱导的支气管收缩（每组P <0.01）。沙丁胺醇（1 μ g/kg iv）显著减弱了乙酰胆碱诱导的杂种犬支气管收缩（P <0.01），但在BG犬中没有。我们的结论是一个质的差异存在于机制中的Na 2 EDTA诱导的收缩在BG的肺外周与杂种狗相比。此外，与杂种犬相比，BG犬的肺外周表现出对胆碱能激发的β-肾上腺素能敏感性降低，表明β-肾上腺素能系统的胆碱能抑制增强。
We studied the ability of a beta-adrenergic agonist (albuterol) to attenuate calcium chelator- and acetylcholine-induced airway constriction in the lung periphery of anesthetized mongrel and Basenji-Greyhound (BG) dogs. A wedged bronchoscope technique was used to measure collateral system resistance before and after challenges with aerosolized Na2EDTA and acetylcholine. Time course of the response to Na2EDTA differed significantly between mongrel and BG dogs. Peak response to challenge with 4% Na2EDTA occurred within 2 min for mongrel dogs and at 5 min for BG dogs. Albuterol (1 microgram/kg iv) significantly attenuated Na2EDTA-induced bronchoconstriction in both groups of animals (P less than 0.01, each group). Albuterol (1 microgram/kg iv) significantly attenuated acetylcholine-induced bronchoconstriction in mongrel (P less than 0.01) but not in BG dogs. We conclude that a qualitative difference exists in the mechanism of Na2EDTA-induced constriction in the lung periphery of BG compared with mongrel dogs. In addition, the lung periphery of BG dogs demonstrates reduced beta-adrenergic sensitivity with respect to a cholinergic challenge compared with mongrels, suggesting enhanced cholinergic inhibition of the beta-adrenergic system.