Postirradiation treatment outcomes for children with acute lymphocytic leukemia: clarification of risks.
Postirradiation treatment outcomes for children with acute lymphocytic leukemia: clarification of risks.
复制标题
急性淋巴细胞白血病儿童的放射治疗结果：风险澄清。
DOI：
10.1093/jpepsy/12.3.395
复制
发表时间：
1987
影响因子：
3.6
通讯作者：
Bierl,PG
中科院分区：
文献类型：
--
作者：
Taylor,HG;Albo,VC;Phebus,CK;Sachs,BR;Bierl,PG
对26名急性淋巴细胞白血病（ALL）幸存的小学儿童进行了发育和教育后果的研究。所有幸存者都接受了颅骨照射作为治疗的一部分。通过比较每个ALL幸存者与一个正常兄弟姐妹的综合测试以及行为和学校表现的措施来评估风险。与之前的研究结果一致，ALL组在智商、神经心理技能和学业成绩测试中的表现不如他们的兄弟姐妹。对家长和老师的评分分析显示，ALL组满足学校学业要求的能力较差，但在行为调整方面与兄弟姐妹组没有差异。更多的儿童从ALL组获得边缘低平均全量表智商分数;更多的学校接受特殊教育援助。然而，这些儿童都不符合智力迟钝的标准。目前的研究结果有助于澄清与治疗方案相关的风险，包括放射治疗。
Developmental and educational consequences of treatment for acute lymphocytic leukemia (ALL) were examined in a group of 26 elementary school children who were survivors of the disease. All of the survivors had received cranial irradiation as part of their treatment. Risks were assessed by comparing each ALL survivor to one normal sibling on a comprehensive battery of tests and on measures of behavior and school performance. Consistent with previous findings, the ALL group performed less well than their siblings on tests of IQ, neuropsychological skills, and academic achievement. Analysis of ratings by parents and teachers revealed that the ALL group was less able to meet the academic demands of school but did not differ from the sibling group in behavioral adjustment. A greater number of children from the ALL group obtained borderline to low-average full-scale IQ scores; and more received special educational assistance at school. However, none of these children met criteria for mental retardation. The present findings help to clarify the risks associated with treatment protocols that include prophylac tic irradiation.