Predictive impact for postoperative recurrence using the preoperative prognostic nutritional index in pathological stage I non-small cell lung cancer
Predictive impact for postoperative recurrence using the preoperative prognostic nutritional index in pathological stage I non-small cell lung cancer
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DOI：
10.1016/j.lungcan.2016.05.010
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发表时间：
2016-08-01
期刊：
影响因子：
5.3
通讯作者：
Maehara, Yoshihiko
中科院分区：
文献类型：
--
作者：
Shoji, Fumihiro;Morodomi, Yosuke;Maehara, Yoshihiko
背景：早期非小细胞肺癌（NSCLC）最有效的治疗方法是手术切除。然而，高达20%的患者，即使是I期NSCLC患者，在手术后复发并死亡。预后营养指数（PNI）用于评估免疫营养状况或预测消化系统恶性肿瘤患者术后复发。然而，PNI对肺癌的有用性仍然是未知的。我们回顾性分析了I期非小细胞肺癌患者的临床病理特征，以确定复发的预测因素，并探讨术前PNI levels.Methods的影响：我们选择了141个连续的I期非小细胞肺癌患者从2005年8月至2010年8月接受治疗。结果：低PNI与性别（P = 0.0117）、术前血清癌胚抗原水平（P = 0.0228）和术后复发（P < 0.0001）显著相关。多因素分析中，PNI（RR：9.243，95%CI：3.662-25.823; P
Background: The most effective treatment for early-stage non-small cell lung cancer (NSCLC) is surgical resection. Nevertheless, up to 20% of patients, even those with stage I NSCLC, relapse after surgery and die. The prognostic nutritional index (PNI) is used to assess immunonutritional conditions or is a predictor of postoperative recurrence in patients with digestive malignancies. However, the usefulness of the PNI for lung cancer is still unknown. We retrospectively analyzed clinicopathological features of stage I NSCLC patients to identify predictors of recurrence and to investigate effects of preoperative PNI levels.Methods: We selected 141 consecutive stage I NSCLC patients who were treated from August 2005 to August 2010. We measured their preoperative PNI levels in uni- and multivariate Cox regression analyses of recurrence-free survival.Results: A low PNI was significantly associated with sex (P = 0.0117), preoperative serum carcino embryonic antigen levels (P = 0.0228), and postoperative recurrence (P < 0.0001). In multivariate analysis, PNI (RR: 9.243; 95% CI: 3.662-25.823; P