Ultrahigh-Density Array of Silver Nanoclusters for SERS Substrate with High Sensitivity and Excellent Reproducibility
Ultrahigh-Density Array of Silver Nanoclusters for SERS Substrate with High Sensitivity and Excellent Reproducibility
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DOI：
10.1021/nn2035236
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发表时间：
2012-01-01
期刊：
影响因子：
17.1
通讯作者：
Kim, Jin Kon
中科院分区：
文献类型：
--
作者：
Cho, Won Joon;Kim, Youngsuk;Kim, Jin Kon
我们介绍了一种简单但强大的方法来制造超高密度的银纳米团簇阵列的表面增强拉曼光谱（Sers）基板具有高灵敏度和良好的再现性在一个非常大的面积（晶圆级）的基础上聚苯乙烯-嵌段-聚（4-乙烯基吡啶）共聚物（PS-b-P4 VP）胶束。在将银硝酸盐掺入胶束核（P4 VP）中之后，接着还原成银纳米团簇，我们系统地控制两个相邻银纳米团簇之间差距距离在8至61 nm的范围内，而每个银纳米团簇的直径保持几乎恒定（类似于25 nm）。为了制备间隙距离为8 nm的银纳米团簇阵列，需要使用平头型胶束。所制备的具有8 nm间隙距离的Sers基底显示出非常高的信号强度，Sers增强因子高达10（8），这足以检测单个分子，并且显示出优异的信号强度再现性（小于+/-5%）。这是因为银纳米团簇在大面积上具有均匀的尺寸和间隙距离。该基底还可用于无标记免疫测定、生物传感和纳米级光学天线和光源。
We introduce a simple but robust method to fabricate an ultrahigh-density array of silver nanoclusters for a surface-enhanced Raman spectroscopy (SERS) substrate with high sensitivity and excellent reproducibility at a very large area (wafer scale) based on polystyrene-block-poly(4-vinylpyridine) copolymer (PS-b-P4VP) micelles. After silver nitrates were incorporated into the micelle cores (P4VP) followed by the reduction to silver nanoclusters, we systematically controlled the gap distance between two neighboring silver nanoclusters ranging from 8 to 61 nm, while the diameter of each silver nanocluster was kept nearly constant (similar to 25 nm). To make a silver nanocluster array with a gap distance of 8 nm, the use of crew-cut-type micelles is required. Fabricated SERS substrate with a gap distance of 8 nm showed very high signal intensity with a SERS enhancement factor as high as 10(8), which is enough to detect a single molecule, and excellent reproducibility (less than +/-5%) of the signal intensity. This is because of the uniform size and gap distance of silver nanoclusters in a large area. The substrate could also be used for label-free immunoassays, biosensing, and nanoscale optical antennas and light sources.