Competing endogenous RNA networks and gastric cancer
Competing endogenous RNA networks and gastric cancer
复制标题
竞争性内源性 RNA 网络与胃癌
DOI：
10.3748/wjg.v21.i41.11680
复制
发表时间：
2015-11-07
影响因子：
4.3
通讯作者：
Wang, Kai-Juan
中科院分区：
文献类型：
--
作者：
Guo, Lei-Lei;Song, Chun-Hua;Wang, Kai-Juan
最近的研究表明，RNA通过微小RNA(MiRNA)反应元件(MRE)相互调节，这种机制被称为竞争内源RNA(Cerna)假说。长的非编码RNA(IncRNAs)被认为在癌症中发挥重要作用。令人信服的证据表明，lncRNAs可以与miRNAs相互作用，并调控miRNAs作为ceRNAs的表达。已发现H19、HOTAIR和MEG3等几个lncRNAs与胃癌(GC)中的miRNAs相关，从而在转录组中产生调控串扰。这些涉及Cerna网络的MRE共享元件(CeRNETs)能够调节mRNA的表达。CERNAs的调控网络包括mRNAs、miRNAs、lncRNAs和环状RNAs，可能在肿瘤的发生中起关键作用，CERNETs的扰动可能参与了GC的发病机制。
Recent studies have showed that RNAs regulate each other with microRNA (miRNA) response elements (MREs) and this mechanism is known as "competing endogenous RNA (ceRNA)" hypothesis. Long non-coding RNAs (IncRNAs) are supposed to play important roles in cancer. Compelling evidence suggests that lncRNAs can interact with miRNAs and regulate the expression of miRNAs as ceRNAs. Several lncRNAs such as H19, HOTAIR and MEG3 have been found to be associated with miRNAs in gastric cancer (GC), generating regulatory crosstalk across the transcriptome. These MRE sharing elements implicated in the ceRNA networks (ceRNETs) are able to regulate mRNA expression. The ceRNA regulatory networks including mRNAs, miRNAs, lncRNAs and circular RNAs may play critical roles in tumorigenesis, and the perturbations of ceRNETs may contribute to the pathogenesis of GC.