Associations of body composition measures and C2, a marker for small artery elasticity: The MESA.
Associations of body composition measures and C2, a marker for small artery elasticity: The MESA.
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DOI：
10.1002/oby.21221
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发表时间：
2015-11
期刊：
影响因子：
--
通讯作者：
Jacobs DR Jr
中科院分区：
文献类型：
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作者：
Forbang NI;Allison MA;Ix JH;Criqui MH;Vaidya D;Yeboah J;Duprez DA;Jacobs DR Jr
较低的 C2 是一种连续血压波形特征，据称代表小动脉弹性，可以预测未来的心血管疾病 (CVD) 事件。我们假设体重指数 (BMI) 和 C2 之间矛盾的正相关可能反映的是肌肉而不是多余的脂肪。在一个由 1,960 名参与者组成的多种族社区生活队列中，我们使用腹部计算机断层扫描 (CT) 扫描来测量内脏脂肪组织 (VAT) 和总腹部肌肉组织 (TAMT)，并使用桡动脉压平张力测量来评估 C2。然后，我们确定了 BMI、TAMT 和 VAT 与 C2 之间的时期横截面关联性。平均年龄为 62 ± 9 岁，其中 50% 为男性。调整年龄、性别、种族、吸烟年数、糖尿病、高血压、总胆固醇和 HDL 胆固醇后，较高的 BMI（标准化 beta = 0.09，p 值 < 0.01）和较高的 TAMT（标准化 beta = 0.12，p 值 < .01）与较高的 C2 显着相关。相反，较高的增值税（标准化 beta = -0.09，p 值 < .01）与较低的 C2 相关。在多变量分析中，与 TAMT 和 BMI 相比，VAT 与顺应性较低的小动脉相关。与体重指数相比，内脏脂肪可能是有害的过量身体脂肪更好的标志。
Lower C2, a continuous blood pressure waveform characteristic asserted to represent small artery elasticity, predicts future cardiovascular disease (CVD) events. We hypothesized that the paradoxical positive association between body mass index (BMI) and C2 may reflect muscle instead of excess fat. In a multi-ethnic, community living cohort of 1,960 participants, we used computed tomography (CT) scans of the abdomen to measure visceral adipose tissue (VAT) and total abdominal muscle tissue (TAMT), and used applanation tonometry of the radial arteries to assess C2. We then ascertained the period cross-sectional associations between BMI, TAMT, and VAT with C2. The mean age was 62 ± 9 years and 50% male. After adjustments for age, gender, ethnicity, pack years smoking cigarettes, diabetes, hypertension, total and HDL cholesterol, higher BMI (standardized beta = 0.09, p-value < 0.01) and more TAMT (standardized beta = 0.12, p-value < .01), were significantly associated with higher C2. In contrast, more VAT (standardized beta = -0.09, p-value < .01) was associated with lower C2. In multivariable analysis, VAT, in contrast to TAMT and BMI was associated with less compliant small arteries. Visceral fat may be a better marker for detrimental excess body fat than BMI.