Sensing pulmonary oxidative stress by lung vagal afferents.
Sensing pulmonary oxidative stress by lung vagal afferents.
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DOI：
10.1016/j.resp.2011.05.003
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发表时间：
2011-09-30
影响因子：
2.3
通讯作者：
Undem, Bradley J.
中科院分区：
文献类型：
--
作者：
Taylor-Clark, Thomas E.;Undem, Bradley J.
关键词：
支气管肺气道中的氧化应激可通过多种炎症机制发生，也可在吸入环境污染物后发生。氧化应激导致细胞功能障碍，因此哺乳动物（包括人类）已经开发出检测氧化应激的机制，使得可以诱导防御行为和防御生物学机制以减轻其潜在的损害。支配气道的迷走感觉神经在气道微环境的检测中起关键作用。氧化应激和相关化合物激活无髓鞘支气管平滑肌C-纤维，在这些神经中引发动作电位，这些神经中枢传导以引起不愉快的感觉（例如，渴望咳嗽、呼吸困难、胸闷）并刺激/调节反射（例如，咳嗽、支气管收缩、呼吸频率、吸气驱动）。这篇综述将总结已发表的关于氧化应激、活性氧、环境污染物和脂质过氧化产物激活支气管肺泡C纤维的机制的证据。有证据表明瞬时受体电位锚蛋白1（TRPA 1）的关键作用，尽管瞬时受体电位香草酸1（TRPV 1）和嘌呤能P2 X通道也可能发挥作用。这些途径的知识极大地帮助我们理解氧化应激在健康和疾病中的作用，并代表了气道疾病的新治疗靶点。
Oxidative stress in the bronchopulmonary airways can occur through a variety of inflammatory mechanisms and also following the inhalation of environmental pollutants. Oxidative stress causes cellular dysfunction and thus mammals (including humans) have developed mechanisms for detecting oxidative stress, such that defensive behavior and defensive biological mechanisms can be induced to lessen its potential damage. Vagal sensory nerves innervating the airways play a critical role in the detection of the microenvironment in the airways. Oxidative stress and associated compounds activate unmyelinated bronchopulmonary C-fibers, initiating action potentials in these nerves that conduct centrally to evoke unpleasant sensations (e.g. urge to cough, dyspnea, chest-tightness) and to stimulate/modulate reflexes (e.g. cough, bronchoconstriction, respiratory rate, inspiratory drive). This review will summarize the published evidence regarding the mechanisms by which oxidative stress, reactive oxygen species, environmental pollutants and lipid products of peroxidation activate bronchopulmonary C-fibers. Evidence suggests a key role for transient receptor potential ankyrin 1 (TRPA1), although transient receptor potential vanilloid 1 (TRPV1) and purinergic P2X channels may also play a role. Knowledge of these pathways greatly aids our understanding of the role of oxidative stress in health and disease and represents novel therapeutic targets for diseases of the airways.
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DOI：
10.1523/jneurosci.5369-07.2008
发表时间：
2008-03-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3.3
作者：
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影响因子：
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作者：
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