Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract
Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract
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DOI：
10.1038/nm0102-54
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发表时间：
2002-01-01
期刊：
影响因子：
82.9
通讯作者：
Braciale, TJ
中科院分区：
文献类型：
--
作者：
Chang, J;Braciale, TJ
呼吸道合胞病毒（RSV）是婴幼儿和老年人呼吸道感染的主要致病原因。目前没有针对RSV的有效疫苗，RSV感染自然史的研究表明，抗原相关病毒株的重复感染在个体一生中很常见。我们研究了实验性小鼠RSV感染过程中的CD8（+）T细胞应答，发现RSV通过干扰TCR介导的信号传导，抑制浸润肺实质的活化RSV特异性CD8（+）T细胞的效应活性表达和肺CD8（+）T细胞记忆的发展。这些数据提示了一种可能的机制来解释RSV感染中保护性免疫的有限持续时间。
Respiratory syncytial virus (RSV) is a major cause of morbidity from respiratory infection in infants, young children and the elderly. No effective vaccine against RSV is currently available and studies of the natural history of RSV infection suggest repeated infections with antigenically related virus strains are common throughout an individual's lifetime. We have studied the CD8(+) T-cell response during experimental murine RSV infection and found that RSV inhibits the expression of effector activity by activated RSV-specific CD8(+) T cells infiltrating the lung parenchyma and the development of pulmonary CD8(+) T-cell memory by interfering with TCR-mediated signaling. These data suggest a possible mechanism to explain the limited duration of protective immunity in RSV infection.