Functional and structural brain changes associated with methamphetamine abuse.
Functional and structural brain changes associated with methamphetamine abuse.
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DOI：
10.3390/brainsci2040434
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发表时间：
2012-10-01
期刊：
影响因子：
3.3
通讯作者：
Russell BR
中科院分区：
文献类型：
--
作者：
Jan RK;Kydd RR;Russell BR
甲基苯丙胺（MA）是一种强效精神兴奋剂，近年来滥用已成为全球流行病。本文首先简要介绍了甲基苯丙胺依赖的流行病学和临床药理学研究进展。其次，本文回顾了有关甲基苯丙胺依赖动物模型的文献，并讨论了甲基苯丙胺诱导神经毒性的可能机制。第三，它提供了一个关键的审查功能和结构的神经影像学研究在人类滥用MA，包括正电子发射断层扫描（PET）和功能和结构磁共振成像（MRI）。还审查了在这些研究范围内短期和长期戒断甲基苯丙胺的影响。
Methamphetamine (MA) is a potent psychostimulant drug whose abuse has become a global epidemic in recent years. Firstly, this review article briefly discusses the epidemiology and clinical pharmacology of methamphetamine dependence. Secondly, the article reviews relevant animal literature modeling methamphetamine dependence and discusses possible mechanisms of methamphetamine-induced neurotoxicity. Thirdly, it provides a critical review of functional and structural neuroimaging studies in human MA abusers; including positron emission tomography (PET) and functional and structural magnetic resonance imaging (MRI). The effect of abstinence from methamphetamine, both short- and long-term within the context of these studies is also reviewed.