Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography
Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography
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DOI：
10.1007/s00259-011-1877-y
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发表时间：
2011-11-01
影响因子：
9.1
通讯作者：
Kaufmann, Philipp A.
中科院分区：
文献类型：
--
作者：
Fiechter, Michael;Ghadri, Jelena R.;Kaufmann, Philipp A.
目的评价一种新的混合单光子发射计算机断层扫描（SPECT）/CT装置对衰减校正核心肌灌注成像（MPI）诊断冠状动脉疾病（CAD）的准确性。侵入性冠状动脉造影作为标准的reference.Methods的研究人群包括66例患者（79%的男性，平均年龄63 +/- 11岁）谁接受了1天的Tc-99 m-tetrofosmin药理学负荷/休息检查和血管造影在3个月内。计算了CT X线衰减校正CZT MPI检测CAD的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）以及准确性（每千日元50%管腔狭窄）。敏感性，特异性，PPV，NPV和准确性分别为87，67，92，53和83%.Conclusion在这第一份报告中，CZT SPECT/CT MPI比较与血管造影，我们证实了血管造影记录的CAD检测的准确性高。
Purpose We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference.Methods The study population included 66 patients (79% men; mean age 63 +/- 11 years) who underwent 1-day Tc-99m-tetrofosmin pharmacological stress/rest examination and angiography within 3 months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (a parts per thousand yen50% luminal narrowing) was calculated on a per-patient basis.Results The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively.Conclusion In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD.